Forskning ved Københavns Universitet - Københavns Universitet

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Glucose balance and muscle glycogen during TPN in the early post-operative phase

Publikation: Forskning - peer reviewTidsskriftartikel

S Henneberg, H Stjernström, B Essén-Gustavsson, L Wiklund

In order to study how muscle glycogen is influenced by different nutritional regimens in the early post-operative period we took muscle biopsies from 20 patients preoperatively and on the fourth post-operative day after abdominal aortic surgery. Ten patients received 93% of non-protein energy as glucose, 7% as fat (Intralipid) and insulin was given to keep the blood glucose below 10 mmol/l. The remaining patients had 80% of non-protein energy as fat (Intralipid). Amino acids constituting 12 g of nitrogen daily were given to both groups. Daily measurements of gas exchange (oxygen uptake, CO2-production) were performed and from these data glucose balance was calculated as the difference between glucose intake and glucose expenditure. Muscle biopsies were analysed for glycogen, adenosine triphosphate, glucose-6-phosphate, lactate and citrate. We found that it was possible to maintain muscle glycogen stores at pre-operative levels with a glucose-insulin regimen. With the fat regimen there was a 31% decrease in muscle glycogen and two patients had a negative glucose balance despite the fact that 150 g of glucose were given. Average glucose balance throughout the study correlated positively with glucose intake. A significant correlation between glucose on the third day and change in muscle glycogen content was found. Muscle content of adenosine triphosphate, glucose-6-phosphate, lactate and citrate were similar in both groups.
OriginalsprogEngelsk
TidsskriftClinical Nutrition
Vol/bind4
Tidsskriftsnummer4
Sider (fra-til)243-7
Antal sider5
ISSN0261-5614
StatusUdgivet - 1 nov. 1985

ID: 34100084