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Glucose turnover during insulin-induced hypoglycemia in liver-denervated rats

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Standard

Glucose turnover during insulin-induced hypoglycemia in liver-denervated rats. / Mikines, K J; Sonne, B; Richter, Erik; Christensen, N J; Galbo, H.

I: American Journal of Physiology (Consolidated), Bind 248, Nr. 3 Pt 1, 1985, s. E327-E332.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Mikines, KJ, Sonne, B, Richter, E, Christensen, NJ & Galbo, H 1985, 'Glucose turnover during insulin-induced hypoglycemia in liver-denervated rats', American Journal of Physiology (Consolidated), bind 248, nr. 3 Pt 1, s. E327-E332.

APA

Mikines, K. J., Sonne, B., Richter, E., Christensen, N. J., & Galbo, H. (1985). Glucose turnover during insulin-induced hypoglycemia in liver-denervated rats. American Journal of Physiology (Consolidated), 248(3 Pt 1), E327-E332.

Vancouver

Mikines KJ, Sonne B, Richter E, Christensen NJ, Galbo H. Glucose turnover during insulin-induced hypoglycemia in liver-denervated rats. American Journal of Physiology (Consolidated). 1985;248(3 Pt 1):E327-E332.

Author

Mikines, K J ; Sonne, B ; Richter, Erik ; Christensen, N J ; Galbo, H. / Glucose turnover during insulin-induced hypoglycemia in liver-denervated rats. I: American Journal of Physiology (Consolidated). 1985 ; Bind 248, Nr. 3 Pt 1. s. E327-E332.

Bibtex

@article{4e3f94a7286b4dc9b4f9a6ec215e6b01,
title = "Glucose turnover during insulin-induced hypoglycemia in liver-denervated rats",
abstract = "The role of hepatic autonomic nerves in glucose production during hypoglycemia was studied. Selective, surgical denervation of the liver was performed in rats, which reduced hepatic norepinephrine concentrations by 96{\%}. Hypoglycemia was induced by 250 mU of insulin intra-arterially in anesthetized as well as in chronically catheterized, awake rats. Half of the anesthetized denervated or sham-operated rats had previously been adrenodemedullated. Glucose turnover was measured by primed, constant intravenous infusion of [3-3H]glucose. Before as well as during hypoglycemia the arterial glucose concentration and rates of production and utilization of glucose were similar in denervated rats and control rats. Also hepatic glycogen depletion was similar in the groups. The lack of effect of denervation could not be ascribed to compensating changes in hormone or substrate levels. In adrenodemedullated rats lack of glucose recovery from hypoglycemia was accompanied by delayed normalization of glucose clearance. In fed rats, activity in hepatic autonomic nerves is not a primary mechanism increasing glucose production during acute hypoglycemia. Epinephrine enhances glucose recovery by decreasing glucose clearance rather than by increasing glucose production, at least when glucagon is present.",
keywords = "Adrenal Cortex Hormones, Adrenal Medulla, Animals, Autonomic Nervous System, Blood Glucose, Denervation, Epinephrine, Gluconeogenesis, Glucose, Hypoglycemia, Insulin, Liver, Male, Rats, Rats, Inbred Strains",
author = "Mikines, {K J} and B Sonne and Erik Richter and Christensen, {N J} and H Galbo",
year = "1985",
language = "English",
volume = "248",
pages = "E327--E332",
journal = "American Journal of Physiology (Consolidated)",
issn = "0002-9513",
publisher = "American Physiological Society",
number = "3 Pt 1",

}

RIS

TY - JOUR

T1 - Glucose turnover during insulin-induced hypoglycemia in liver-denervated rats

AU - Mikines, K J

AU - Sonne, B

AU - Richter, Erik

AU - Christensen, N J

AU - Galbo, H

PY - 1985

Y1 - 1985

N2 - The role of hepatic autonomic nerves in glucose production during hypoglycemia was studied. Selective, surgical denervation of the liver was performed in rats, which reduced hepatic norepinephrine concentrations by 96%. Hypoglycemia was induced by 250 mU of insulin intra-arterially in anesthetized as well as in chronically catheterized, awake rats. Half of the anesthetized denervated or sham-operated rats had previously been adrenodemedullated. Glucose turnover was measured by primed, constant intravenous infusion of [3-3H]glucose. Before as well as during hypoglycemia the arterial glucose concentration and rates of production and utilization of glucose were similar in denervated rats and control rats. Also hepatic glycogen depletion was similar in the groups. The lack of effect of denervation could not be ascribed to compensating changes in hormone or substrate levels. In adrenodemedullated rats lack of glucose recovery from hypoglycemia was accompanied by delayed normalization of glucose clearance. In fed rats, activity in hepatic autonomic nerves is not a primary mechanism increasing glucose production during acute hypoglycemia. Epinephrine enhances glucose recovery by decreasing glucose clearance rather than by increasing glucose production, at least when glucagon is present.

AB - The role of hepatic autonomic nerves in glucose production during hypoglycemia was studied. Selective, surgical denervation of the liver was performed in rats, which reduced hepatic norepinephrine concentrations by 96%. Hypoglycemia was induced by 250 mU of insulin intra-arterially in anesthetized as well as in chronically catheterized, awake rats. Half of the anesthetized denervated or sham-operated rats had previously been adrenodemedullated. Glucose turnover was measured by primed, constant intravenous infusion of [3-3H]glucose. Before as well as during hypoglycemia the arterial glucose concentration and rates of production and utilization of glucose were similar in denervated rats and control rats. Also hepatic glycogen depletion was similar in the groups. The lack of effect of denervation could not be ascribed to compensating changes in hormone or substrate levels. In adrenodemedullated rats lack of glucose recovery from hypoglycemia was accompanied by delayed normalization of glucose clearance. In fed rats, activity in hepatic autonomic nerves is not a primary mechanism increasing glucose production during acute hypoglycemia. Epinephrine enhances glucose recovery by decreasing glucose clearance rather than by increasing glucose production, at least when glucagon is present.

KW - Adrenal Cortex Hormones

KW - Adrenal Medulla

KW - Animals

KW - Autonomic Nervous System

KW - Blood Glucose

KW - Denervation

KW - Epinephrine

KW - Gluconeogenesis

KW - Glucose

KW - Hypoglycemia

KW - Insulin

KW - Liver

KW - Male

KW - Rats

KW - Rats, Inbred Strains

M3 - Journal article

C2 - 3883803

VL - 248

SP - E327-E332

JO - American Journal of Physiology (Consolidated)

JF - American Journal of Physiology (Consolidated)

SN - 0002-9513

IS - 3 Pt 1

ER -

ID: 154758878