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Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice

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Standard

Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice. / Bugge, T H; Kombrinck, K W; Xiao, Q; Holmbäck, K; Daugherty, C C; Witte, D P; Degen, J L.

I: Blood, Bind 90, Nr. 11, 01.12.1997, s. 4522-31.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bugge, TH, Kombrinck, KW, Xiao, Q, Holmbäck, K, Daugherty, CC, Witte, DP & Degen, JL 1997, 'Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice', Blood, bind 90, nr. 11, s. 4522-31.

APA

Bugge, T. H., Kombrinck, K. W., Xiao, Q., Holmbäck, K., Daugherty, C. C., Witte, D. P., & Degen, J. L. (1997). Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice. Blood, 90(11), 4522-31.

Vancouver

Bugge TH, Kombrinck KW, Xiao Q, Holmbäck K, Daugherty CC, Witte DP o.a. Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice. Blood. 1997 dec 1;90(11):4522-31.

Author

Bugge, T H ; Kombrinck, K W ; Xiao, Q ; Holmbäck, K ; Daugherty, C C ; Witte, D P ; Degen, J L. / Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice. I: Blood. 1997 ; Bind 90, Nr. 11. s. 4522-31.

Bibtex

@article{665e91f8dfda4a9584ce490090e56e0b,
title = "Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice",
abstract = "Plasminogen activation has been proposed to play a critical role in cancer invasion and metastasis. The effects of complete ablation of plasminogen activation in cancer was studied by inoculation of a metastatic Lewis lung carcinoma expressing high levels of plasminogen activator into plasminogen-deficient (Plg-/-) mice and matched control mice. Primary tumors developed in all mice with no difference in the rate of appearance between Plg-/- and control mice. However, the primary tumors in Plg-/- mice were smaller and less hemorrhagic and displayed reduced skin ulceration. In addition, dissemination of the tumor to regional lymph nodes was delayed in Plg-/- mice. Surprisingly, no quantitative differences were observed in lung metastasis between Plg-/- and control mice. In addition, Plg deficiency was compatible with metastasis of the primary tumor to a variety of other organs. Nevertheless, Plg-/- mice displayed a moderately increased survival after primary tumor resection. These findings suggest that plasmin-mediated proteolysis contributes to the morbidity and mortality of Lewis lung carcinoma in mice, but sufficient proteolytic activity is generated in Plg-/- mice for efficient tumor development and metastasis.",
keywords = "Animals, Carcinoma, Lewis Lung/mortality, Fibrinolysin/metabolism, Mice, Mice, Inbred C57BL, Neoplasm Invasiveness/pathology, Neoplasm Metastasis/pathology, Neoplasm Transplantation, Plasminogen/deficiency, Plasminogen Activator Inhibitor 1/metabolism, Urokinase-Type Plasminogen Activator/metabolism",
author = "Bugge, {T H} and Kombrinck, {K W} and Q Xiao and K Holmb{\"a}ck and Daugherty, {C C} and Witte, {D P} and Degen, {J L}",
year = "1997",
month = dec,
day = "1",
language = "English",
volume = "90",
pages = "4522--31",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "11",

}

RIS

TY - JOUR

T1 - Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice

AU - Bugge, T H

AU - Kombrinck, K W

AU - Xiao, Q

AU - Holmbäck, K

AU - Daugherty, C C

AU - Witte, D P

AU - Degen, J L

PY - 1997/12/1

Y1 - 1997/12/1

N2 - Plasminogen activation has been proposed to play a critical role in cancer invasion and metastasis. The effects of complete ablation of plasminogen activation in cancer was studied by inoculation of a metastatic Lewis lung carcinoma expressing high levels of plasminogen activator into plasminogen-deficient (Plg-/-) mice and matched control mice. Primary tumors developed in all mice with no difference in the rate of appearance between Plg-/- and control mice. However, the primary tumors in Plg-/- mice were smaller and less hemorrhagic and displayed reduced skin ulceration. In addition, dissemination of the tumor to regional lymph nodes was delayed in Plg-/- mice. Surprisingly, no quantitative differences were observed in lung metastasis between Plg-/- and control mice. In addition, Plg deficiency was compatible with metastasis of the primary tumor to a variety of other organs. Nevertheless, Plg-/- mice displayed a moderately increased survival after primary tumor resection. These findings suggest that plasmin-mediated proteolysis contributes to the morbidity and mortality of Lewis lung carcinoma in mice, but sufficient proteolytic activity is generated in Plg-/- mice for efficient tumor development and metastasis.

AB - Plasminogen activation has been proposed to play a critical role in cancer invasion and metastasis. The effects of complete ablation of plasminogen activation in cancer was studied by inoculation of a metastatic Lewis lung carcinoma expressing high levels of plasminogen activator into plasminogen-deficient (Plg-/-) mice and matched control mice. Primary tumors developed in all mice with no difference in the rate of appearance between Plg-/- and control mice. However, the primary tumors in Plg-/- mice were smaller and less hemorrhagic and displayed reduced skin ulceration. In addition, dissemination of the tumor to regional lymph nodes was delayed in Plg-/- mice. Surprisingly, no quantitative differences were observed in lung metastasis between Plg-/- and control mice. In addition, Plg deficiency was compatible with metastasis of the primary tumor to a variety of other organs. Nevertheless, Plg-/- mice displayed a moderately increased survival after primary tumor resection. These findings suggest that plasmin-mediated proteolysis contributes to the morbidity and mortality of Lewis lung carcinoma in mice, but sufficient proteolytic activity is generated in Plg-/- mice for efficient tumor development and metastasis.

KW - Animals

KW - Carcinoma, Lewis Lung/mortality

KW - Fibrinolysin/metabolism

KW - Mice

KW - Mice, Inbred C57BL

KW - Neoplasm Invasiveness/pathology

KW - Neoplasm Metastasis/pathology

KW - Neoplasm Transplantation

KW - Plasminogen/deficiency

KW - Plasminogen Activator Inhibitor 1/metabolism

KW - Urokinase-Type Plasminogen Activator/metabolism

M3 - Journal article

C2 - 9373263

VL - 90

SP - 4522

EP - 4531

JO - Blood

JF - Blood

SN - 0006-4971

IS - 11

ER -

ID: 201190164