Forskning ved Københavns Universitet - Københavns Universitet


Health-Related Quality of Life after surgery for primary advanced rectal cancer and recurrent rectal cancer: a review

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Henriette Vind Thaysen
  • Per Jess
  • Søren Laurberg
Aim: A review of the literature was undertaken to provide an overview of Health-related quality of life (HRQoL) after surgery for primary advanced or recurrent rectal cancer and to outline proposals for future HRQoL studies in this area. Method: A systematic literature search was undertaken. Only studies concerning surgery for primary advanced or recurrent rectal cancer and describing methods used for measuring HRQoL were considered. Results Seven studies were identified including two prospective longitudinal, three cross-sectional and two based on qualitative data. Global quality of life, physical, social, role and sexual function seemed to be impaired for a varying time after surgery. All the studies had methodical problems due to small sample size (12-44 patients) and different points of time for the assessment of HRQoL (12.3-47 months) which made it difficult to determine the period of time of impaired HRQoL and also if this is different after surgery for locally advanced or recurrent disease than after total mesorectal excision used for earlier tumours.. Conclusion Several aspects of HRQoL are impaired for a variable time after treatment for locally advanced or recurrence of rectal cancer. Larger prospective longitudinal studies are needed to improve information on the effects of this extensive surgery on quality of life.
TidsskriftColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
Udgave nummer7
Sider (fra-til)797-803
StatusUdgivet - 2012

ID: 33638544