Forskning ved Københavns Universitet - Københavns Universitet

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Hepatitis B and C co-infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Amanda Mocroft
  • Jacqueline Neuhaus
  • Lars Peters
  • Lene Ryom
  • Markus Bickel
  • Daniel Grint
  • Janak Koirala
  • Aleksandra Szymczak
  • Lundgren, Jens
  • Michael J Ross
  • Christina M Wyatt
  • INSIGHT SMART Study Group
Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-positive individuals. Hepatitis C (HCV) co-infection has been associated with increased risk of CKD, but prior studies lack information on potential mechanisms. We evaluated the association between HCV or hepatitis B (HBV) co-infection and progressive CKD among 3,441 antiretroviral-treated clinical trial participants. Progressive CKD was defined as the composite of end-stage renal disease, renal death, or significant glomerular filtration rate (eGFR) decline (25% decline to eGFR 800,000 IU/ml had increased odds (OR 3.07; 95% CI 1.60-5.90). Interleukin-6, hyaluronic acid, and the FIB-4 hepatic fibrosis index were higher among participants who developed progressive CKD, but were no longer associated with progressive CKD after adjustment. Future studies should validate the relationship between HCV viremia and CKD. Trial registration: ClinicalTrials.gov NCT00027352; NCT00004978.
OriginalsprogEngelsk
TidsskriftPLOS ONE
Vol/bind7
Udgave nummer7
Sider (fra-til)e40245
ISSN1932-6203
DOI
StatusUdgivet - 2012

ID: 48911012