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High glucose impairs superoxide production from isolated blood neutrophils

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Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.
OriginalsprogEngelsk
TidsskriftIntensive Care Medicine
Vol/bind29
Udgave nummer4
Sider (fra-til)642-5
Antal sider4
ISSN0342-4642
DOI
StatusUdgivet - apr. 2003

ID: 48553034