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High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis

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Standard

High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis. / Gasim, S; Elhassan, A M; Khalil, E A; Ismail, A; Kadaru, A M; Kharazmi, A; Theander, T G.

I: Clinical and Experimental Immunology, Bind 111, Nr. 1, 1998, s. 64-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Gasim, S, Elhassan, AM, Khalil, EA, Ismail, A, Kadaru, AM, Kharazmi, A & Theander, TG 1998, 'High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis', Clinical and Experimental Immunology, bind 111, nr. 1, s. 64-9.

APA

Gasim, S., Elhassan, A. M., Khalil, E. A., Ismail, A., Kadaru, A. M., Kharazmi, A., & Theander, T. G. (1998). High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis. Clinical and Experimental Immunology, 111(1), 64-9.

Vancouver

Gasim S, Elhassan AM, Khalil EA, Ismail A, Kadaru AM, Kharazmi A o.a. High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis. Clinical and Experimental Immunology. 1998;111(1):64-9.

Author

Gasim, S ; Elhassan, A M ; Khalil, E A ; Ismail, A ; Kadaru, A M ; Kharazmi, A ; Theander, T G. / High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis. I: Clinical and Experimental Immunology. 1998 ; Bind 111, Nr. 1. s. 64-9.

Bibtex

@article{c89d8750a0d811dd86a6000ea68e967b,
title = "High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis",
abstract = "Some patients develop post-kala-azar dermal leishmaniasis (PKDL) after they have been treated for the systemic infection kala-azar (visceral leishmaniasis). It has been an enigma why the parasites cause skin symptoms after the patients have been successfully treated for the systemic disease. We report here that PKDL development can be predicted before treatment of visceral leishmaniasis, and that IL-10 is involved in the pathogenesis. Before treatment of visceral leishmaniasis, Leishmania parasites were present in skin which appeared normal on all patients. However, IL-10 was detected in the keratinocytes and/or sweat glands of all patients who later developed PKDL (group 1) and not in any of the patients who did not develop PKDL (group 2). Furthermore, the levels of IL-10 in plasma as well as in peripheral blood mononuclear cell culture supernatants were higher in group 1 than in group 2.",
author = "S Gasim and Elhassan, {A M} and Khalil, {E A} and A Ismail and Kadaru, {A M} and A Kharazmi and Theander, {T G}",
note = "Keywords: Adolescent; Adult; Biological Markers; Child; Female; Humans; Interleukin-10; Keratinocytes; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Male; Predictive Value of Tests",
year = "1998",
language = "English",
volume = "111",
pages = "64--9",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis

AU - Gasim, S

AU - Elhassan, A M

AU - Khalil, E A

AU - Ismail, A

AU - Kadaru, A M

AU - Kharazmi, A

AU - Theander, T G

N1 - Keywords: Adolescent; Adult; Biological Markers; Child; Female; Humans; Interleukin-10; Keratinocytes; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Male; Predictive Value of Tests

PY - 1998

Y1 - 1998

N2 - Some patients develop post-kala-azar dermal leishmaniasis (PKDL) after they have been treated for the systemic infection kala-azar (visceral leishmaniasis). It has been an enigma why the parasites cause skin symptoms after the patients have been successfully treated for the systemic disease. We report here that PKDL development can be predicted before treatment of visceral leishmaniasis, and that IL-10 is involved in the pathogenesis. Before treatment of visceral leishmaniasis, Leishmania parasites were present in skin which appeared normal on all patients. However, IL-10 was detected in the keratinocytes and/or sweat glands of all patients who later developed PKDL (group 1) and not in any of the patients who did not develop PKDL (group 2). Furthermore, the levels of IL-10 in plasma as well as in peripheral blood mononuclear cell culture supernatants were higher in group 1 than in group 2.

AB - Some patients develop post-kala-azar dermal leishmaniasis (PKDL) after they have been treated for the systemic infection kala-azar (visceral leishmaniasis). It has been an enigma why the parasites cause skin symptoms after the patients have been successfully treated for the systemic disease. We report here that PKDL development can be predicted before treatment of visceral leishmaniasis, and that IL-10 is involved in the pathogenesis. Before treatment of visceral leishmaniasis, Leishmania parasites were present in skin which appeared normal on all patients. However, IL-10 was detected in the keratinocytes and/or sweat glands of all patients who later developed PKDL (group 1) and not in any of the patients who did not develop PKDL (group 2). Furthermore, the levels of IL-10 in plasma as well as in peripheral blood mononuclear cell culture supernatants were higher in group 1 than in group 2.

M3 - Journal article

C2 - 9472662

VL - 111

SP - 64

EP - 69

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 1

ER -

ID: 6766112