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High risk of pulmonary embolism and deep venous thrombosis but not of stroke in granulomatosis with polyangiitis (Wegener's)

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Standard

High risk of pulmonary embolism and deep venous thrombosis but not of stroke in granulomatosis with polyangiitis (Wegener's). / Faurschou, Mikkel; Obel, Niels; Baslund, Bo.

I: Arthritis Care & Research, Bind 66, Nr. 12, 12.2014, s. 1910–1914.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Faurschou, M, Obel, N & Baslund, B 2014, 'High risk of pulmonary embolism and deep venous thrombosis but not of stroke in granulomatosis with polyangiitis (Wegener's)', Arthritis Care & Research, bind 66, nr. 12, s. 1910–1914. https://doi.org/10.1002/acr.22423

APA

Faurschou, M., Obel, N., & Baslund, B. (2014). High risk of pulmonary embolism and deep venous thrombosis but not of stroke in granulomatosis with polyangiitis (Wegener's). Arthritis Care & Research, 66(12), 1910–1914. https://doi.org/10.1002/acr.22423

Vancouver

Faurschou M, Obel N, Baslund B. High risk of pulmonary embolism and deep venous thrombosis but not of stroke in granulomatosis with polyangiitis (Wegener's). Arthritis Care & Research. 2014 dec;66(12):1910–1914. https://doi.org/10.1002/acr.22423

Author

Faurschou, Mikkel ; Obel, Niels ; Baslund, Bo. / High risk of pulmonary embolism and deep venous thrombosis but not of stroke in granulomatosis with polyangiitis (Wegener's). I: Arthritis Care & Research. 2014 ; Bind 66, Nr. 12. s. 1910–1914.

Bibtex

@article{c045bb8da3fd4ac787971c671069cb45,
title = "High risk of pulmonary embolism and deep venous thrombosis but not of stroke in granulomatosis with polyangiitis (Wegener's)",
abstract = "OBJECTIVE: To assess the incidence of stroke, pulmonary embolism (PE), and deep venous thrombosis (DVT) in granulomatosis with polyangiitis (Wegener's) (GPA).METHODS: Patients diagnosed with GPA at a Danish tertiary care center during 1993-2011 were identified (n = 180). Each patient was matched with 19 population controls (n = 3,420). Information on hospitalizations for stroke, PE, and DVT was obtained from the Danish National Hospital Register. The occurrence of vascular events in the GPA cohort was compared with that in the control group by calculation of incidence rate ratios (IRRs).RESULTS: The median duration of followup was 7.2 years (interquartile range 3.1-11.7 years) in the GPA cohort. Within the first 2 years following the diagnosis of vasculitis, the incidences of PE and DVT were substantially increased among the patients (IRR 25.7 [95% confidence interval (95% CI) 6.9-96] for PE and IRR 20.2 [95% CI 5.1-81] for DVT). The incidence of stroke was not increased during this time interval (IRR 1.4 [95% CI 0.3-5.7]). From 2 years after GPA diagnosis, an increased incidence was found for DVT (IRR 4.5 [95% CI 1.7-11.8]) but not for PE (IRR 1.3 [95% CI 0.2-9.6]) or stroke (IRR 1.4 [95% CI 0.6-3.3]). In the GPA cohort, 70% of the vascular events occurred during phases with active vasculitis.CONCLUSION: The present study confirms that GPA patients have a markedly increased risk of venous thromboembolism. We did not observe an increased risk of stroke in our cohort. Thus, our observations demonstrate a differential impact of GPA and/or its treatment on the risk of various vascular events.",
keywords = "Adult, Female, Granulomatosis with Polyangiitis, Humans, Incidence, Male, Middle Aged, Pulmonary Embolism, Risk, Stroke, Venous Thrombosis",
author = "Mikkel Faurschou and Niels Obel and Bo Baslund",
note = "Copyright {\textcopyright} 2014 by the American College of Rheumatology.",
year = "2014",
month = dec,
doi = "10.1002/acr.22423",
language = "English",
volume = "66",
pages = "1910–1914",
journal = "Arthritis Care & Research",
issn = "2151-464X",
publisher = "Wiley",
number = "12",

}

RIS

TY - JOUR

T1 - High risk of pulmonary embolism and deep venous thrombosis but not of stroke in granulomatosis with polyangiitis (Wegener's)

AU - Faurschou, Mikkel

AU - Obel, Niels

AU - Baslund, Bo

N1 - Copyright © 2014 by the American College of Rheumatology.

PY - 2014/12

Y1 - 2014/12

N2 - OBJECTIVE: To assess the incidence of stroke, pulmonary embolism (PE), and deep venous thrombosis (DVT) in granulomatosis with polyangiitis (Wegener's) (GPA).METHODS: Patients diagnosed with GPA at a Danish tertiary care center during 1993-2011 were identified (n = 180). Each patient was matched with 19 population controls (n = 3,420). Information on hospitalizations for stroke, PE, and DVT was obtained from the Danish National Hospital Register. The occurrence of vascular events in the GPA cohort was compared with that in the control group by calculation of incidence rate ratios (IRRs).RESULTS: The median duration of followup was 7.2 years (interquartile range 3.1-11.7 years) in the GPA cohort. Within the first 2 years following the diagnosis of vasculitis, the incidences of PE and DVT were substantially increased among the patients (IRR 25.7 [95% confidence interval (95% CI) 6.9-96] for PE and IRR 20.2 [95% CI 5.1-81] for DVT). The incidence of stroke was not increased during this time interval (IRR 1.4 [95% CI 0.3-5.7]). From 2 years after GPA diagnosis, an increased incidence was found for DVT (IRR 4.5 [95% CI 1.7-11.8]) but not for PE (IRR 1.3 [95% CI 0.2-9.6]) or stroke (IRR 1.4 [95% CI 0.6-3.3]). In the GPA cohort, 70% of the vascular events occurred during phases with active vasculitis.CONCLUSION: The present study confirms that GPA patients have a markedly increased risk of venous thromboembolism. We did not observe an increased risk of stroke in our cohort. Thus, our observations demonstrate a differential impact of GPA and/or its treatment on the risk of various vascular events.

AB - OBJECTIVE: To assess the incidence of stroke, pulmonary embolism (PE), and deep venous thrombosis (DVT) in granulomatosis with polyangiitis (Wegener's) (GPA).METHODS: Patients diagnosed with GPA at a Danish tertiary care center during 1993-2011 were identified (n = 180). Each patient was matched with 19 population controls (n = 3,420). Information on hospitalizations for stroke, PE, and DVT was obtained from the Danish National Hospital Register. The occurrence of vascular events in the GPA cohort was compared with that in the control group by calculation of incidence rate ratios (IRRs).RESULTS: The median duration of followup was 7.2 years (interquartile range 3.1-11.7 years) in the GPA cohort. Within the first 2 years following the diagnosis of vasculitis, the incidences of PE and DVT were substantially increased among the patients (IRR 25.7 [95% confidence interval (95% CI) 6.9-96] for PE and IRR 20.2 [95% CI 5.1-81] for DVT). The incidence of stroke was not increased during this time interval (IRR 1.4 [95% CI 0.3-5.7]). From 2 years after GPA diagnosis, an increased incidence was found for DVT (IRR 4.5 [95% CI 1.7-11.8]) but not for PE (IRR 1.3 [95% CI 0.2-9.6]) or stroke (IRR 1.4 [95% CI 0.6-3.3]). In the GPA cohort, 70% of the vascular events occurred during phases with active vasculitis.CONCLUSION: The present study confirms that GPA patients have a markedly increased risk of venous thromboembolism. We did not observe an increased risk of stroke in our cohort. Thus, our observations demonstrate a differential impact of GPA and/or its treatment on the risk of various vascular events.

KW - Adult

KW - Female

KW - Granulomatosis with Polyangiitis

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Pulmonary Embolism

KW - Risk

KW - Stroke

KW - Venous Thrombosis

U2 - 10.1002/acr.22423

DO - 10.1002/acr.22423

M3 - Journal article

C2 - 25073637

VL - 66

SP - 1910

EP - 1914

JO - Arthritis Care & Research

JF - Arthritis Care & Research

SN - 2151-464X

IS - 12

ER -

ID: 137743221