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House dust mite control measures for asthma: systematic review

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House dust mite control measures for asthma: systematic review. / Gøtzsche, Peter C.; Johansen, Helle Krogh.

I: Allergy. European Journal of Allergy and Clinical Immunology, Bind 63, Nr. 6, 2008, s. 646-659.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Gøtzsche, PC & Johansen, HK 2008, 'House dust mite control measures for asthma: systematic review', Allergy. European Journal of Allergy and Clinical Immunology, bind 63, nr. 6, s. 646-659.

APA

Gøtzsche, P. C., & Johansen, H. K. (2008). House dust mite control measures for asthma: systematic review. Allergy. European Journal of Allergy and Clinical Immunology, 63(6), 646-659.

Vancouver

Gøtzsche PC, Johansen HK. House dust mite control measures for asthma: systematic review. Allergy. European Journal of Allergy and Clinical Immunology. 2008;63(6):646-659.

Author

Gøtzsche, Peter C. ; Johansen, Helle Krogh. / House dust mite control measures for asthma: systematic review. I: Allergy. European Journal of Allergy and Clinical Immunology. 2008 ; Bind 63, Nr. 6. s. 646-659.

Bibtex

@article{acad8010f75711ddbf70000ea68e967b,
title = "House dust mite control measures for asthma: systematic review",
abstract = "The major allergen in house dust comes from mites. We performed a systematic review of the randomized trials that had assessed the effects of reducing exposure to house dust mite antigens in the homes of people with mite-sensitive asthma, and had compared active interventions with placebo or no treatment. Fifty-four trials (3002 patients) were included. Thirty-six trials assessed physical methods (26 mattress covers), 10 chemical methods and eight a combination of chemical and physical methods. Despite the fact that many trials were of poor quality and would be expected to exaggerate the reported effect, we did not find an effect of the interventions. For the most frequently reported outcome, peak flow in the morning (1565 patients), the standardized mean difference was 0.00 (95% confidence interval (CI) -0.10 to 0.10). There were no statistically significant differences in number of patients improved (relative risk 1.01, 95% CI 0.80-1.27), asthma symptom scores (standardized mean difference -0.04, 95% CI -0.15 to 0.07) or in medication usage (standardized mean difference -0.06, 95% CI -0.18 to 0.07). Chemical and physical methods aimed at reducing exposure to house dust mite allergens cannot be recommended Udgivelsesdato: 2008/6",
author = "G{\o}tzsche, {Peter C.} and Johansen, {Helle Krogh}",
year = "2008",
language = "English",
volume = "63",
pages = "646--659",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley Online",
number = "6",

}

RIS

TY - JOUR

T1 - House dust mite control measures for asthma: systematic review

AU - Gøtzsche, Peter C.

AU - Johansen, Helle Krogh

PY - 2008

Y1 - 2008

N2 - The major allergen in house dust comes from mites. We performed a systematic review of the randomized trials that had assessed the effects of reducing exposure to house dust mite antigens in the homes of people with mite-sensitive asthma, and had compared active interventions with placebo or no treatment. Fifty-four trials (3002 patients) were included. Thirty-six trials assessed physical methods (26 mattress covers), 10 chemical methods and eight a combination of chemical and physical methods. Despite the fact that many trials were of poor quality and would be expected to exaggerate the reported effect, we did not find an effect of the interventions. For the most frequently reported outcome, peak flow in the morning (1565 patients), the standardized mean difference was 0.00 (95% confidence interval (CI) -0.10 to 0.10). There were no statistically significant differences in number of patients improved (relative risk 1.01, 95% CI 0.80-1.27), asthma symptom scores (standardized mean difference -0.04, 95% CI -0.15 to 0.07) or in medication usage (standardized mean difference -0.06, 95% CI -0.18 to 0.07). Chemical and physical methods aimed at reducing exposure to house dust mite allergens cannot be recommended Udgivelsesdato: 2008/6

AB - The major allergen in house dust comes from mites. We performed a systematic review of the randomized trials that had assessed the effects of reducing exposure to house dust mite antigens in the homes of people with mite-sensitive asthma, and had compared active interventions with placebo or no treatment. Fifty-four trials (3002 patients) were included. Thirty-six trials assessed physical methods (26 mattress covers), 10 chemical methods and eight a combination of chemical and physical methods. Despite the fact that many trials were of poor quality and would be expected to exaggerate the reported effect, we did not find an effect of the interventions. For the most frequently reported outcome, peak flow in the morning (1565 patients), the standardized mean difference was 0.00 (95% confidence interval (CI) -0.10 to 0.10). There were no statistically significant differences in number of patients improved (relative risk 1.01, 95% CI 0.80-1.27), asthma symptom scores (standardized mean difference -0.04, 95% CI -0.15 to 0.07) or in medication usage (standardized mean difference -0.06, 95% CI -0.18 to 0.07). Chemical and physical methods aimed at reducing exposure to house dust mite allergens cannot be recommended Udgivelsesdato: 2008/6

M3 - Journal article

VL - 63

SP - 646

EP - 659

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 6

ER -

ID: 10244086