Forskning ved Københavns Universitet - Københavns Universitet


How long can bacteriophage λ change its mind?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

A key event in the lifecycle of a temperate bacteriophage is the choice between lysis and lysogeny upon infection of a susceptible host cell. In a recent paper, we showed that a prolonged period exists after the decision to lysogenize, during which bacteriophage λ can abandon the initial decision, and instead develop lytically, as a response to the accumulation of the late lytic regulatory protein Q. Here, we present evidence that expression of Q does not induce replication of λ DNA, suggesting that the DNA to be packaged into the resulting phage progeny was already present at the time of the initial decision to lysogenize. We summarize our findings in a working model of the key determinants of the duration of the post-decision period during which it is possible for the infected cell to switch from the lysogeny decision to successful lytic development.

Udgave nummer1
Sider (fra-til)e1012930
StatusUdgivet - 16 okt. 2015
Eksternt udgivetJa

ID: 163917127