Forskning ved Københavns Universitet - Københavns Universitet

Forside

Huntingtin gene repeat size variations affect risk of lifetime depression

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Dokumenter

  • Sarah L. Gardiner
  • Martine J. van Belzen
  • Merel W. Boogaard
  • Willeke M. C. van Roon-Mom
  • Rozing, Maarten Pieter
  • Albert M. van Hemert
  • Johannes H. Smit
  • Aartjan T. F. Beekman
  • Gerard van Grootheest
  • Robert A. Schoevers
  • Richard C. Oude Voshaar
  • Raymund A. C. Roos
  • Hannie C. Comijs
  • Brenda W. J. H. Penninx
  • Roos C. van der Mast
  • N. Ahmad Aziz
Huntington disease (HD) is a severe neuropsychiatric disorder caused by a cytosine-adenine-guanine (CAG) repeat expansion in the HTT gene. Although HD is frequently complicated by depression, it is still unknown to what extent common HTT CAG repeat size variations in the normal range could affect depression risk in the general population. Using binary logistic regression, we assessed the association between HTT CAG repeat size and depression risk in two well-characterized Dutch cohorts─the Netherlands Study of Depression and Anxiety and the Netherlands Study of Depression in Older Persons─including 2165 depressed and 1058 non-depressed persons. In both cohorts, separately as well as combined, there was a significant non-linear association between the risk of lifetime depression and HTT CAG repeat size in which both relatively short and relatively large alleles were associated with an increased risk of depression (β = −0.292 and β = 0.006 for the linear and the quadratic term, respectively; both P < 0.01 after adjustment for the effects of sex, age, and education level). The odds of lifetime depression were lowest in persons with a HTT CAG repeat size of 21 (odds ratio: 0.71, 95% confidence interval: 0.52 to 0.98) compared to the average odds in the total cohort. In conclusion, lifetime depression risk was higher with both relatively short and relatively large HTT CAG repeat sizes in the normal range. Our study provides important proof-of-principle that repeat polymorphisms can act as hitherto unappreciated but complex genetic modifiers of depression.
OriginalsprogEngelsk
Artikelnummer1277
TidsskriftTranslational Psychiatry
Vol/bind7
Sider (fra-til)1-8
Antal sider8
ISSN2158-3188
DOI
StatusUdgivet - 11 dec. 2017

Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk


Ingen data tilgængelig

ID: 188414234