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Hypotension during endotoxemia in aged humans

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Hypotension during endotoxemia in aged humans. / Krabbe, Karen Suarez; Kemp, Helle Bruunsgaard; Qvist, Jesper; Hansen, Christian Muff; Møller, Kirsten; Fonsmark, Lise; Madsen, Per Lav; Kronborg, Gitte; Frandsen, U; Andersen, H.Ørbæk; Skinhøj, Peter; Pedersen, Bente Klarlund.

I: European Journal of Anaesthesiology, Bind 18, Nr. 9, 31.12.2001, s. 572-575.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Krabbe, KS, Kemp, HB, Qvist, J, Hansen, CM, Møller, K, Fonsmark, L, Madsen, PL, Kronborg, G, Frandsen, U, Andersen, HØ, Skinhøj, P & Pedersen, BK 2001, 'Hypotension during endotoxemia in aged humans', European Journal of Anaesthesiology, bind 18, nr. 9, s. 572-575.

APA

Krabbe, K. S., Kemp, H. B., Qvist, J., Hansen, C. M., Møller, K., Fonsmark, L., ... Pedersen, B. K. (2001). Hypotension during endotoxemia in aged humans. European Journal of Anaesthesiology, 18(9), 572-575.

Vancouver

Krabbe KS, Kemp HB, Qvist J, Hansen CM, Møller K, Fonsmark L o.a. Hypotension during endotoxemia in aged humans. European Journal of Anaesthesiology. 2001 dec 31;18(9):572-575.

Author

Krabbe, Karen Suarez ; Kemp, Helle Bruunsgaard ; Qvist, Jesper ; Hansen, Christian Muff ; Møller, Kirsten ; Fonsmark, Lise ; Madsen, Per Lav ; Kronborg, Gitte ; Frandsen, U ; Andersen, H.Ørbæk ; Skinhøj, Peter ; Pedersen, Bente Klarlund. / Hypotension during endotoxemia in aged humans. I: European Journal of Anaesthesiology. 2001 ; Bind 18, Nr. 9. s. 572-575.

Bibtex

@article{905f3d885ae84dda9d51b9d47bbae809,
title = "Hypotension during endotoxemia in aged humans",
abstract = "BACKGROUND: and objective The aim of this study was to determine possible age-associated differences in human blood pressure regulation during an immunological challenge in healthy subjects. METHODS: Eight healthy young volunteers (median age 24 yr) and nine healthy elderly volunteers (median age 66 yr) received an intravenous bolus injection of Escherichia coli endotoxin (2 ng kg(-1)). Blood pressure, heart rate and core temperature were monitored during the first 7 h. Plasma catecholamine concentrations were measured at hourly intervals. RESULTS: The elderly showed a significantly more pronounced decrease in mean arterial pressure 4-7 h after endotoxin administration compared with the young controls (ANOVA; age x time; P < 0.0005). This mainly reflected a decrease in the systolic blood pressure in the elderly. The heart rate of both groups increased without difference between groups. Increased plasma epinephrine concentrations were found 2-3 h after endotoxin administration in both groups. Five hours after the endotoxin challenge, the epinephrine concentration had returned to control values in the elderly group only, in spite of decreased blood pressure. CONCLUSION: In conclusion, healthy elderly subjects fail to maintain a constant mean arterial pressure in response to the immunological challenge of endotoxemia.",
author = "Krabbe, {Karen Suarez} and Kemp, {Helle Bruunsgaard} and Jesper Qvist and Hansen, {Christian Muff} and Kirsten M{\o}ller and Lise Fonsmark and Madsen, {Per Lav} and Gitte Kronborg and U Frandsen and H.{\O}rb{\ae}k Andersen and Peter Skinh{\o}j and Pedersen, {Bente Klarlund}",
year = "2001",
month = "12",
day = "31",
language = "Dansk",
volume = "18",
pages = "572--575",
journal = "European Journal of Anaesthesiology",
issn = "0265-0215",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - Hypotension during endotoxemia in aged humans

AU - Krabbe, Karen Suarez

AU - Kemp, Helle Bruunsgaard

AU - Qvist, Jesper

AU - Hansen, Christian Muff

AU - Møller, Kirsten

AU - Fonsmark, Lise

AU - Madsen, Per Lav

AU - Kronborg, Gitte

AU - Frandsen, U

AU - Andersen, H.Ørbæk

AU - Skinhøj, Peter

AU - Pedersen, Bente Klarlund

PY - 2001/12/31

Y1 - 2001/12/31

N2 - BACKGROUND: and objective The aim of this study was to determine possible age-associated differences in human blood pressure regulation during an immunological challenge in healthy subjects. METHODS: Eight healthy young volunteers (median age 24 yr) and nine healthy elderly volunteers (median age 66 yr) received an intravenous bolus injection of Escherichia coli endotoxin (2 ng kg(-1)). Blood pressure, heart rate and core temperature were monitored during the first 7 h. Plasma catecholamine concentrations were measured at hourly intervals. RESULTS: The elderly showed a significantly more pronounced decrease in mean arterial pressure 4-7 h after endotoxin administration compared with the young controls (ANOVA; age x time; P < 0.0005). This mainly reflected a decrease in the systolic blood pressure in the elderly. The heart rate of both groups increased without difference between groups. Increased plasma epinephrine concentrations were found 2-3 h after endotoxin administration in both groups. Five hours after the endotoxin challenge, the epinephrine concentration had returned to control values in the elderly group only, in spite of decreased blood pressure. CONCLUSION: In conclusion, healthy elderly subjects fail to maintain a constant mean arterial pressure in response to the immunological challenge of endotoxemia.

AB - BACKGROUND: and objective The aim of this study was to determine possible age-associated differences in human blood pressure regulation during an immunological challenge in healthy subjects. METHODS: Eight healthy young volunteers (median age 24 yr) and nine healthy elderly volunteers (median age 66 yr) received an intravenous bolus injection of Escherichia coli endotoxin (2 ng kg(-1)). Blood pressure, heart rate and core temperature were monitored during the first 7 h. Plasma catecholamine concentrations were measured at hourly intervals. RESULTS: The elderly showed a significantly more pronounced decrease in mean arterial pressure 4-7 h after endotoxin administration compared with the young controls (ANOVA; age x time; P < 0.0005). This mainly reflected a decrease in the systolic blood pressure in the elderly. The heart rate of both groups increased without difference between groups. Increased plasma epinephrine concentrations were found 2-3 h after endotoxin administration in both groups. Five hours after the endotoxin challenge, the epinephrine concentration had returned to control values in the elderly group only, in spite of decreased blood pressure. CONCLUSION: In conclusion, healthy elderly subjects fail to maintain a constant mean arterial pressure in response to the immunological challenge of endotoxemia.

M3 - Tidsskriftartikel

VL - 18

SP - 572

EP - 575

JO - European Journal of Anaesthesiology

JF - European Journal of Anaesthesiology

SN - 0265-0215

IS - 9

ER -

ID: 162987358