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Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

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Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. / Ji, Xuemei; Bossé, Yohan; Landi, Maria Teresa; Gui, Jiang; Xiao, Xiangjun; Qian, David; Joubert, Philippe; Lamontagne, Maxime; Li, Yafang; Gorlov, Ivan; de Biasi, Mariella; Han, Younghun; Gorlova, Olga; Hung, Rayjean J; Wu, Xifeng; McKay, James; Zong, Xuchen; Carreras-Torres, Robert; Christiani, David C; Caporaso, Neil; Johansson, Mattias; Liu, Geoffrey; Bojesen, Stig E; Le Marchand, Loic; Albanes, Demetrios; Bickeböller, Heike; Aldrich, Melinda C; Bush, William S; Tardon, Adonina; Rennert, Gad; Chen, Chu; Teare, M Dawn; Field, John K; Kiemeney, Lambertus A; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthew B; Andrew, Angeline S; Shen, Hongbing; Hong, Yun-Chul; Yuan, Jian-Min; Bertazzi, Pier A; Pesatori, Angela C; Ye, Yuanqing; Diao, Nancy; Su, Li; Zhang, Ruyang; Brhane, Yonathan; Leighl, Natasha; Johansen, Jakob S; Mellemgaard, Anders; Saliba, Walid; Haiman, Christopher; Wilkens, Lynne; Fernandez-Somoano, Ana; Fernandez-Tardon, Guillermo; van der Heijden, Erik H F M; Kim, Jin Hee; Dai, Juncheng; Hu, Zhibin; Davies, Michael P A; Marcus, Michael W; Brunnström, Hans; Manjer, Jonas; Melander, Olle; Muller, David C; Overvad, Kim; Trichopoulou, Antonia; Tumino, Rosario; Doherty, Jennifer; Goodman, Gary E; Cox, Angela; Taylor, Fiona; Woll, Penella; Brüske, Irene; Manz, Judith; Muley, Thomas; Risch, Angela; Rosenberger, Albert; Grankvist, Kjell; Johansson, Mikael; Shepherd, Frances; Tsao, Ming-Sound; Arnold, Susanne M; Haura, Eric B; Bolca, Ciprian; Holcatova, Ivana; Janout, Vladimir; Kontic, Milica; Lissowska, Jolanta; Mukeria, Anush; Ognjanovic, Simona; Orlowski, Tadeusz M; Scelo, Ghislaine; Swiatkowska, Beata; Zaridze, David; Bakke, Per; Skaug, Vidar; Zienolddiny, Shanbeh; Duell, Eric J; Butler, Lesley M; Koh, Woon-Puay; Gao, Yu-Tang; Houlston, Richard; McLaughlin, John; Stevens, Victoria; Nickle, David C; Obeidat, Ma'en; Timens, Wim; Zhu, Bin; Song, Lei; Artigas, María Soler; Tobin, Martin D; Wain, Louise V; Gu, Fangyi; Byun, Jinyoung; Kamal, Ahsan; Zhu, Dakai; Tyndale, Rachel F; Wei, Wei-Qi; Chanock, Stephen; Brennan, Paul; Amos, Christopher I.

I: Nature Communications, Bind 9, 3221, 2018.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Ji, X, Bossé, Y, Landi, MT, Gui, J, Xiao, X, Qian, D, Joubert, P, Lamontagne, M, Li, Y, Gorlov, I, de Biasi, M, Han, Y, Gorlova, O, Hung, RJ, Wu, X, McKay, J, Zong, X, Carreras-Torres, R, Christiani, DC, Caporaso, N, Johansson, M, Liu, G, Bojesen, SE, Le Marchand, L, Albanes, D, Bickeböller, H, Aldrich, MC, Bush, WS, Tardon, A, Rennert, G, Chen, C, Teare, MD, Field, JK, Kiemeney, LA, Lazarus, P, Haugen, A, Lam, S, Schabath, MB, Andrew, AS, Shen, H, Hong, Y-C, Yuan, J-M, Bertazzi, PA, Pesatori, AC, Ye, Y, Diao, N, Su, L, Zhang, R, Brhane, Y, Leighl, N, Johansen, JS, Mellemgaard, A, Saliba, W, Haiman, C, Wilkens, L, Fernandez-Somoano, A, Fernandez-Tardon, G, van der Heijden, EHFM, Kim, JH, Dai, J, Hu, Z, Davies, MPA, Marcus, MW, Brunnström, H, Manjer, J, Melander, O, Muller, DC, Overvad, K, Trichopoulou, A, Tumino, R, Doherty, J, Goodman, GE, Cox, A, Taylor, F, Woll, P, Brüske, I, Manz, J, Muley, T, Risch, A, Rosenberger, A, Grankvist, K, Johansson, M, Shepherd, F, Tsao, M-S, Arnold, SM, Haura, EB, Bolca, C, Holcatova, I, Janout, V, Kontic, M, Lissowska, J, Mukeria, A, Ognjanovic, S, Orlowski, TM, Scelo, G, Swiatkowska, B, Zaridze, D, Bakke, P, Skaug, V, Zienolddiny, S, Duell, EJ, Butler, LM, Koh, W-P, Gao, Y-T, Houlston, R, McLaughlin, J, Stevens, V, Nickle, DC, Obeidat, M, Timens, W, Zhu, B, Song, L, Artigas, MS, Tobin, MD, Wain, LV, Gu, F, Byun, J, Kamal, A, Zhu, D, Tyndale, RF, Wei, W-Q, Chanock, S, Brennan, P & Amos, CI 2018, 'Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk', Nature Communications, bind 9, 3221. https://doi.org/10.1038/s41467-018-05074-y

APA

Ji, X., Bossé, Y., Landi, M. T., Gui, J., Xiao, X., Qian, D., ... Amos, C. I. (2018). Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nature Communications, 9, [3221]. https://doi.org/10.1038/s41467-018-05074-y

Vancouver

Ji X, Bossé Y, Landi MT, Gui J, Xiao X, Qian D o.a. Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. Nature Communications. 2018;9. 3221. https://doi.org/10.1038/s41467-018-05074-y

Author

Ji, Xuemei ; Bossé, Yohan ; Landi, Maria Teresa ; Gui, Jiang ; Xiao, Xiangjun ; Qian, David ; Joubert, Philippe ; Lamontagne, Maxime ; Li, Yafang ; Gorlov, Ivan ; de Biasi, Mariella ; Han, Younghun ; Gorlova, Olga ; Hung, Rayjean J ; Wu, Xifeng ; McKay, James ; Zong, Xuchen ; Carreras-Torres, Robert ; Christiani, David C ; Caporaso, Neil ; Johansson, Mattias ; Liu, Geoffrey ; Bojesen, Stig E ; Le Marchand, Loic ; Albanes, Demetrios ; Bickeböller, Heike ; Aldrich, Melinda C ; Bush, William S ; Tardon, Adonina ; Rennert, Gad ; Chen, Chu ; Teare, M Dawn ; Field, John K ; Kiemeney, Lambertus A ; Lazarus, Philip ; Haugen, Aage ; Lam, Stephen ; Schabath, Matthew B ; Andrew, Angeline S ; Shen, Hongbing ; Hong, Yun-Chul ; Yuan, Jian-Min ; Bertazzi, Pier A ; Pesatori, Angela C ; Ye, Yuanqing ; Diao, Nancy ; Su, Li ; Zhang, Ruyang ; Brhane, Yonathan ; Leighl, Natasha ; Johansen, Jakob S ; Mellemgaard, Anders ; Saliba, Walid ; Haiman, Christopher ; Wilkens, Lynne ; Fernandez-Somoano, Ana ; Fernandez-Tardon, Guillermo ; van der Heijden, Erik H F M ; Kim, Jin Hee ; Dai, Juncheng ; Hu, Zhibin ; Davies, Michael P A ; Marcus, Michael W ; Brunnström, Hans ; Manjer, Jonas ; Melander, Olle ; Muller, David C ; Overvad, Kim ; Trichopoulou, Antonia ; Tumino, Rosario ; Doherty, Jennifer ; Goodman, Gary E ; Cox, Angela ; Taylor, Fiona ; Woll, Penella ; Brüske, Irene ; Manz, Judith ; Muley, Thomas ; Risch, Angela ; Rosenberger, Albert ; Grankvist, Kjell ; Johansson, Mikael ; Shepherd, Frances ; Tsao, Ming-Sound ; Arnold, Susanne M ; Haura, Eric B ; Bolca, Ciprian ; Holcatova, Ivana ; Janout, Vladimir ; Kontic, Milica ; Lissowska, Jolanta ; Mukeria, Anush ; Ognjanovic, Simona ; Orlowski, Tadeusz M ; Scelo, Ghislaine ; Swiatkowska, Beata ; Zaridze, David ; Bakke, Per ; Skaug, Vidar ; Zienolddiny, Shanbeh ; Duell, Eric J ; Butler, Lesley M ; Koh, Woon-Puay ; Gao, Yu-Tang ; Houlston, Richard ; McLaughlin, John ; Stevens, Victoria ; Nickle, David C ; Obeidat, Ma'en ; Timens, Wim ; Zhu, Bin ; Song, Lei ; Artigas, María Soler ; Tobin, Martin D ; Wain, Louise V ; Gu, Fangyi ; Byun, Jinyoung ; Kamal, Ahsan ; Zhu, Dakai ; Tyndale, Rachel F ; Wei, Wei-Qi ; Chanock, Stephen ; Brennan, Paul ; Amos, Christopher I. / Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. I: Nature Communications. 2018 ; Bind 9.

Bibtex

@article{acb75a754fe64d5abbd252f8e268879b,
title = "Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk",
abstract = "Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.",
keywords = "Adolescent, Adult, Aged, Child, Child, Preschool, Chromosomes, Human, Pair 15/genetics, Cohort Studies, Female, Gene Ontology, Gene Regulatory Networks, Genetic Predisposition to Disease, Humans, Infant, Infant, Newborn, Lung Neoplasms/genetics, Male, Middle Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci/genetics, Reproducibility of Results, Risk Factors, Smoking/adverse effects, Young Adult",
author = "Xuemei Ji and Yohan Boss{\'e} and Landi, {Maria Teresa} and Jiang Gui and Xiangjun Xiao and David Qian and Philippe Joubert and Maxime Lamontagne and Yafang Li and Ivan Gorlov and {de Biasi}, Mariella and Younghun Han and Olga Gorlova and Hung, {Rayjean J} and Xifeng Wu and James McKay and Xuchen Zong and Robert Carreras-Torres and Christiani, {David C} and Neil Caporaso and Mattias Johansson and Geoffrey Liu and Bojesen, {Stig E} and {Le Marchand}, Loic and Demetrios Albanes and Heike Bickeb{\"o}ller and Aldrich, {Melinda C} and Bush, {William S} and Adonina Tardon and Gad Rennert and Chu Chen and Teare, {M Dawn} and Field, {John K} and Kiemeney, {Lambertus A} and Philip Lazarus and Aage Haugen and Stephen Lam and Schabath, {Matthew B} and Andrew, {Angeline S} and Hongbing Shen and Yun-Chul Hong and Jian-Min Yuan and Bertazzi, {Pier A} and Pesatori, {Angela C} and Yuanqing Ye and Nancy Diao and Li Su and Ruyang Zhang and Yonathan Brhane and Natasha Leighl and Johansen, {Jakob S} and Anders Mellemgaard and Walid Saliba and Christopher Haiman and Lynne Wilkens and Ana Fernandez-Somoano and Guillermo Fernandez-Tardon and {van der Heijden}, {Erik H F M} and Kim, {Jin Hee} and Juncheng Dai and Zhibin Hu and Davies, {Michael P A} and Marcus, {Michael W} and Hans Brunnstr{\"o}m and Jonas Manjer and Olle Melander and Muller, {David C} and Kim Overvad and Antonia Trichopoulou and Rosario Tumino and Jennifer Doherty and Goodman, {Gary E} and Angela Cox and Fiona Taylor and Penella Woll and Irene Br{\"u}ske and Judith Manz and Thomas Muley and Angela Risch and Albert Rosenberger and Kjell Grankvist and Mikael Johansson and Frances Shepherd and Ming-Sound Tsao and Arnold, {Susanne M} and Haura, {Eric B} and Ciprian Bolca and Ivana Holcatova and Vladimir Janout and Milica Kontic and Jolanta Lissowska and Anush Mukeria and Simona Ognjanovic and Orlowski, {Tadeusz M} and Ghislaine Scelo and Beata Swiatkowska and David Zaridze and Per Bakke and Vidar Skaug and Shanbeh Zienolddiny and Duell, {Eric J} and Butler, {Lesley M} and Woon-Puay Koh and Yu-Tang Gao and Richard Houlston and John McLaughlin and Victoria Stevens and Nickle, {David C} and Ma'en Obeidat and Wim Timens and Bin Zhu and Lei Song and Artigas, {Mar{\'i}a Soler} and Tobin, {Martin D} and Wain, {Louise V} and Fangyi Gu and Jinyoung Byun and Ahsan Kamal and Dakai Zhu and Tyndale, {Rachel F} and Wei-Qi Wei and Stephen Chanock and Paul Brennan and Amos, {Christopher I}",
year = "2018",
doi = "10.1038/s41467-018-05074-y",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

AU - Ji, Xuemei

AU - Bossé, Yohan

AU - Landi, Maria Teresa

AU - Gui, Jiang

AU - Xiao, Xiangjun

AU - Qian, David

AU - Joubert, Philippe

AU - Lamontagne, Maxime

AU - Li, Yafang

AU - Gorlov, Ivan

AU - de Biasi, Mariella

AU - Han, Younghun

AU - Gorlova, Olga

AU - Hung, Rayjean J

AU - Wu, Xifeng

AU - McKay, James

AU - Zong, Xuchen

AU - Carreras-Torres, Robert

AU - Christiani, David C

AU - Caporaso, Neil

AU - Johansson, Mattias

AU - Liu, Geoffrey

AU - Bojesen, Stig E

AU - Le Marchand, Loic

AU - Albanes, Demetrios

AU - Bickeböller, Heike

AU - Aldrich, Melinda C

AU - Bush, William S

AU - Tardon, Adonina

AU - Rennert, Gad

AU - Chen, Chu

AU - Teare, M Dawn

AU - Field, John K

AU - Kiemeney, Lambertus A

AU - Lazarus, Philip

AU - Haugen, Aage

AU - Lam, Stephen

AU - Schabath, Matthew B

AU - Andrew, Angeline S

AU - Shen, Hongbing

AU - Hong, Yun-Chul

AU - Yuan, Jian-Min

AU - Bertazzi, Pier A

AU - Pesatori, Angela C

AU - Ye, Yuanqing

AU - Diao, Nancy

AU - Su, Li

AU - Zhang, Ruyang

AU - Brhane, Yonathan

AU - Leighl, Natasha

AU - Johansen, Jakob S

AU - Mellemgaard, Anders

AU - Saliba, Walid

AU - Haiman, Christopher

AU - Wilkens, Lynne

AU - Fernandez-Somoano, Ana

AU - Fernandez-Tardon, Guillermo

AU - van der Heijden, Erik H F M

AU - Kim, Jin Hee

AU - Dai, Juncheng

AU - Hu, Zhibin

AU - Davies, Michael P A

AU - Marcus, Michael W

AU - Brunnström, Hans

AU - Manjer, Jonas

AU - Melander, Olle

AU - Muller, David C

AU - Overvad, Kim

AU - Trichopoulou, Antonia

AU - Tumino, Rosario

AU - Doherty, Jennifer

AU - Goodman, Gary E

AU - Cox, Angela

AU - Taylor, Fiona

AU - Woll, Penella

AU - Brüske, Irene

AU - Manz, Judith

AU - Muley, Thomas

AU - Risch, Angela

AU - Rosenberger, Albert

AU - Grankvist, Kjell

AU - Johansson, Mikael

AU - Shepherd, Frances

AU - Tsao, Ming-Sound

AU - Arnold, Susanne M

AU - Haura, Eric B

AU - Bolca, Ciprian

AU - Holcatova, Ivana

AU - Janout, Vladimir

AU - Kontic, Milica

AU - Lissowska, Jolanta

AU - Mukeria, Anush

AU - Ognjanovic, Simona

AU - Orlowski, Tadeusz M

AU - Scelo, Ghislaine

AU - Swiatkowska, Beata

AU - Zaridze, David

AU - Bakke, Per

AU - Skaug, Vidar

AU - Zienolddiny, Shanbeh

AU - Duell, Eric J

AU - Butler, Lesley M

AU - Koh, Woon-Puay

AU - Gao, Yu-Tang

AU - Houlston, Richard

AU - McLaughlin, John

AU - Stevens, Victoria

AU - Nickle, David C

AU - Obeidat, Ma'en

AU - Timens, Wim

AU - Zhu, Bin

AU - Song, Lei

AU - Artigas, María Soler

AU - Tobin, Martin D

AU - Wain, Louise V

AU - Gu, Fangyi

AU - Byun, Jinyoung

AU - Kamal, Ahsan

AU - Zhu, Dakai

AU - Tyndale, Rachel F

AU - Wei, Wei-Qi

AU - Chanock, Stephen

AU - Brennan, Paul

AU - Amos, Christopher I

PY - 2018

Y1 - 2018

N2 - Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.

AB - Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.

KW - Adolescent

KW - Adult

KW - Aged

KW - Child

KW - Child, Preschool

KW - Chromosomes, Human, Pair 15/genetics

KW - Cohort Studies

KW - Female

KW - Gene Ontology

KW - Gene Regulatory Networks

KW - Genetic Predisposition to Disease

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Lung Neoplasms/genetics

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci/genetics

KW - Reproducibility of Results

KW - Risk Factors

KW - Smoking/adverse effects

KW - Young Adult

U2 - 10.1038/s41467-018-05074-y

DO - 10.1038/s41467-018-05074-y

M3 - Journal article

C2 - 30104567

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 3221

ER -

ID: 216469883