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Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples

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Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples. / Andréasson, Ulrika; Edén, Patrik; Peterson, Carsten; Högerkorp, Carl-Magnus; Jerkeman, Mats; Andersen, Niels Smedegaard; Berglund, Mattias; Sundström, Christer; Rosenquist, Richard; Borrebaeck, Carl A K; Ek, Sara.

I: American Journal of Hematology, Bind 85, Nr. 6, 01.06.2010, s. 418-25.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Andréasson, U, Edén, P, Peterson, C, Högerkorp, C-M, Jerkeman, M, Andersen, NS, Berglund, M, Sundström, C, Rosenquist, R, Borrebaeck, CAK & Ek, S 2010, 'Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples', American Journal of Hematology, bind 85, nr. 6, s. 418-25. https://doi.org/10.1002/ajh.21701

APA

Andréasson, U., Edén, P., Peterson, C., Högerkorp, C-M., Jerkeman, M., Andersen, N. S., ... Ek, S. (2010). Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples. American Journal of Hematology, 85(6), 418-25. https://doi.org/10.1002/ajh.21701

Vancouver

Andréasson U, Edén P, Peterson C, Högerkorp C-M, Jerkeman M, Andersen NS o.a. Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples. American Journal of Hematology. 2010 jun 1;85(6):418-25. https://doi.org/10.1002/ajh.21701

Author

Andréasson, Ulrika ; Edén, Patrik ; Peterson, Carsten ; Högerkorp, Carl-Magnus ; Jerkeman, Mats ; Andersen, Niels Smedegaard ; Berglund, Mattias ; Sundström, Christer ; Rosenquist, Richard ; Borrebaeck, Carl A K ; Ek, Sara. / Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples. I: American Journal of Hematology. 2010 ; Bind 85, Nr. 6. s. 418-25.

Bibtex

@article{2338217d84c14b618cceae620924a950,
title = "Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples",
abstract = "Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repression and transcriptional activation. Still, this information is not used for classification of B-cell lymphomas (BCLs). Traditionally, BCLs are diagnosed based on a phenotypic resemblance to normal B-cells; assessed by immunohistochemistry or flow cytometry, by using a handful of phenotypic markers. In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), providing a new powerful means for the classification, prediction of survival, and response to treatment of lymphomas. However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. In this study, global GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treatment.",
author = "Ulrika Andr{\'e}asson and Patrik Ed{\'e}n and Carsten Peterson and Carl-Magnus H{\"o}gerkorp and Mats Jerkeman and Andersen, {Niels Smedegaard} and Mattias Berglund and Christer Sundstr{\"o}m and Richard Rosenquist and Borrebaeck, {Carl A K} and Sara Ek",
note = "2010 Wiley-Liss, Inc.",
year = "2010",
month = "6",
day = "1",
doi = "http://dx.doi.org/10.1002/ajh.21701",
language = "English",
volume = "85",
pages = "418--25",
journal = "American Journal of Hematology",
issn = "0361-8609",
publisher = "JohnWiley & Sons, Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Identification of uniquely expressed transcription factors in highly purified B-cell lymphoma samples

AU - Andréasson, Ulrika

AU - Edén, Patrik

AU - Peterson, Carsten

AU - Högerkorp, Carl-Magnus

AU - Jerkeman, Mats

AU - Andersen, Niels Smedegaard

AU - Berglund, Mattias

AU - Sundström, Christer

AU - Rosenquist, Richard

AU - Borrebaeck, Carl A K

AU - Ek, Sara

N1 - 2010 Wiley-Liss, Inc.

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repression and transcriptional activation. Still, this information is not used for classification of B-cell lymphomas (BCLs). Traditionally, BCLs are diagnosed based on a phenotypic resemblance to normal B-cells; assessed by immunohistochemistry or flow cytometry, by using a handful of phenotypic markers. In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), providing a new powerful means for the classification, prediction of survival, and response to treatment of lymphomas. However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. In this study, global GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treatment.

AB - Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repression and transcriptional activation. Still, this information is not used for classification of B-cell lymphomas (BCLs). Traditionally, BCLs are diagnosed based on a phenotypic resemblance to normal B-cells; assessed by immunohistochemistry or flow cytometry, by using a handful of phenotypic markers. In the last decade, diagnostic and prognostic evaluation has been facilitated by global gene expression profiling (GEP), providing a new powerful means for the classification, prediction of survival, and response to treatment of lymphomas. However, most GEP studies have typically been performed on whole tissue samples, containing varying degrees of tumor cell content, which results in uncertainties in data analysis. In this study, global GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treatment.

U2 - http://dx.doi.org/10.1002/ajh.21701

DO - http://dx.doi.org/10.1002/ajh.21701

M3 - Journal article

VL - 85

SP - 418

EP - 425

JO - American Journal of Hematology

JF - American Journal of Hematology

SN - 0361-8609

IS - 6

ER -

ID: 34052913