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IgE-mediated basophil tumour necrosis factor alpha induces matrix metalloproteinase-9 from monocytes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

IgE-mediated activation of mast cells has been reported to induce the release of tumour necrosis alpha (TNF-α), which may display autocrine effects on these cells by inducing the generation of the tissue remodelling protease matrix metalloproteinase-9 (MMP-9). While mast cells and basophils have been shown to express complementary and partially overlapping roles, it is not clear whether a similar IgE/TNF-α/MMP-9 axis exists in the human basophil. The purpose of this study was thus to investigate whether IgE-mediated activation of human basophils induces TNF-α and MMP-9 release.
OriginalsprogEngelsk
TidsskriftAllergy: European Journal of Allergy and Clinical Immunology
Vol/bind68
Udgave nummer5
Sider (fra-til)614-620
Antal sider7
ISSN0105-4538
DOI
StatusUdgivet - 2013

ID: 45791918