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IGF-I at 9 and 36 months of age - relations with body composition and diet at 3 years - the SKOT cohort

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IGF-I at 9 and 36 months of age - relations with body composition and diet at 3 years - the SKOT cohort. / Ejlerskov, Katrine Tschentscher; Larnkjær, Anni; Pedersen, Dorthe; Ritz, Christian; Mølgaard, Christian; Michaelsen, Kim F.

I: Growth Hormone & I G F Research, Bind 24, Nr. 6, 2014, s. 239-244.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Ejlerskov, KT, Larnkjær, A, Pedersen, D, Ritz, C, Mølgaard, C & Michaelsen, KF 2014, 'IGF-I at 9 and 36 months of age - relations with body composition and diet at 3 years - the SKOT cohort', Growth Hormone & I G F Research, bind 24, nr. 6, s. 239-244. https://doi.org/10.1016/j.ghir.2014.10.005

APA

Ejlerskov, K. T., Larnkjær, A., Pedersen, D., Ritz, C., Mølgaard, C., & Michaelsen, K. F. (2014). IGF-I at 9 and 36 months of age - relations with body composition and diet at 3 years - the SKOT cohort. Growth Hormone & I G F Research, 24(6), 239-244. https://doi.org/10.1016/j.ghir.2014.10.005

Vancouver

Ejlerskov KT, Larnkjær A, Pedersen D, Ritz C, Mølgaard C, Michaelsen KF. IGF-I at 9 and 36 months of age - relations with body composition and diet at 3 years - the SKOT cohort. Growth Hormone & I G F Research. 2014;24(6):239-244. https://doi.org/10.1016/j.ghir.2014.10.005

Author

Ejlerskov, Katrine Tschentscher ; Larnkjær, Anni ; Pedersen, Dorthe ; Ritz, Christian ; Mølgaard, Christian ; Michaelsen, Kim F. / IGF-I at 9 and 36 months of age - relations with body composition and diet at 3 years - the SKOT cohort. I: Growth Hormone & I G F Research. 2014 ; Bind 24, Nr. 6. s. 239-244.

Bibtex

@article{2275d28f20b746e2a645d0c9261f0cad,
title = "IGF-I at 9 and 36 months of age - relations with body composition and diet at 3 years - the SKOT cohort",
abstract = "OBJECTIVE: High infancy levels of insulin-like growth factor-I (IGF-I) have been associated with increased linear growth and fat-free mass (FFM) but also with risk of obesity. This paper examines how IGF-I at 9 and 36months relates to diet and body composition.DESIGN: Healthy term infants from the prospective cohort study, SKOT, were examined at 9 and 36months with anthropometry, bioelectrical impedance (36months), 7-day food records and blood analysis of IGF-I and IGFBP-3 by chemiluminescent immunometric assay.RESULTS: IGF-I at 36months (n=229) was positively correlated with 9months values and values were considerably higher in girls (43{\%}). Children breastfed at 9months had lower IGF-I concentrations at 9months but reached the same IGF-I concentrations at 36months as infants not breastfed at 9months. IGF-I at 36months was positively associated with height, weight, BMI, predicted FFM and FFM index (FFM/height (kg/m(2))). Although there also was a positive association with predicted fat mass (FM) there was no association with FM index (FM/height (kg/m(2))). Further, a negative association with skin fold thickness was observed. A change in IGF-I from 9-36months was positively related to FFM and FFM index but not BMI, FM and FM index. No associations were seen between IGF-I and current intake of milk, meat or protein energy percentage, but both fat and saturated fat energy percentage were negatively associated with IGF-I.CONCLUSION: IGF-I concentrations were positively associated with growth but not with adiposity at this age. However, the higher tempo of growth may influence age at adiposity rebound and thereby later risk of obesity. Milk and protein intake at 36months did not influence IGF-I but there was a negative association with intake of fat and saturated fat. The implications of this finding for development of obesity need further exploration.",
author = "Ejlerskov, {Katrine Tschentscher} and Anni Larnkj{\ae}r and Dorthe Pedersen and Christian Ritz and Christian M{\o}lgaard and Michaelsen, {Kim F.}",
note = "CURIS 2014 NEXS 360",
year = "2014",
doi = "10.1016/j.ghir.2014.10.005",
language = "English",
volume = "24",
pages = "239--244",
journal = "Growth Hormone & I G F Research",
issn = "1096-6374",
publisher = "Churchill Livingstone",
number = "6",

}

RIS

TY - JOUR

T1 - IGF-I at 9 and 36 months of age - relations with body composition and diet at 3 years - the SKOT cohort

AU - Ejlerskov, Katrine Tschentscher

AU - Larnkjær, Anni

AU - Pedersen, Dorthe

AU - Ritz, Christian

AU - Mølgaard, Christian

AU - Michaelsen, Kim F.

N1 - CURIS 2014 NEXS 360

PY - 2014

Y1 - 2014

N2 - OBJECTIVE: High infancy levels of insulin-like growth factor-I (IGF-I) have been associated with increased linear growth and fat-free mass (FFM) but also with risk of obesity. This paper examines how IGF-I at 9 and 36months relates to diet and body composition.DESIGN: Healthy term infants from the prospective cohort study, SKOT, were examined at 9 and 36months with anthropometry, bioelectrical impedance (36months), 7-day food records and blood analysis of IGF-I and IGFBP-3 by chemiluminescent immunometric assay.RESULTS: IGF-I at 36months (n=229) was positively correlated with 9months values and values were considerably higher in girls (43%). Children breastfed at 9months had lower IGF-I concentrations at 9months but reached the same IGF-I concentrations at 36months as infants not breastfed at 9months. IGF-I at 36months was positively associated with height, weight, BMI, predicted FFM and FFM index (FFM/height (kg/m(2))). Although there also was a positive association with predicted fat mass (FM) there was no association with FM index (FM/height (kg/m(2))). Further, a negative association with skin fold thickness was observed. A change in IGF-I from 9-36months was positively related to FFM and FFM index but not BMI, FM and FM index. No associations were seen between IGF-I and current intake of milk, meat or protein energy percentage, but both fat and saturated fat energy percentage were negatively associated with IGF-I.CONCLUSION: IGF-I concentrations were positively associated with growth but not with adiposity at this age. However, the higher tempo of growth may influence age at adiposity rebound and thereby later risk of obesity. Milk and protein intake at 36months did not influence IGF-I but there was a negative association with intake of fat and saturated fat. The implications of this finding for development of obesity need further exploration.

AB - OBJECTIVE: High infancy levels of insulin-like growth factor-I (IGF-I) have been associated with increased linear growth and fat-free mass (FFM) but also with risk of obesity. This paper examines how IGF-I at 9 and 36months relates to diet and body composition.DESIGN: Healthy term infants from the prospective cohort study, SKOT, were examined at 9 and 36months with anthropometry, bioelectrical impedance (36months), 7-day food records and blood analysis of IGF-I and IGFBP-3 by chemiluminescent immunometric assay.RESULTS: IGF-I at 36months (n=229) was positively correlated with 9months values and values were considerably higher in girls (43%). Children breastfed at 9months had lower IGF-I concentrations at 9months but reached the same IGF-I concentrations at 36months as infants not breastfed at 9months. IGF-I at 36months was positively associated with height, weight, BMI, predicted FFM and FFM index (FFM/height (kg/m(2))). Although there also was a positive association with predicted fat mass (FM) there was no association with FM index (FM/height (kg/m(2))). Further, a negative association with skin fold thickness was observed. A change in IGF-I from 9-36months was positively related to FFM and FFM index but not BMI, FM and FM index. No associations were seen between IGF-I and current intake of milk, meat or protein energy percentage, but both fat and saturated fat energy percentage were negatively associated with IGF-I.CONCLUSION: IGF-I concentrations were positively associated with growth but not with adiposity at this age. However, the higher tempo of growth may influence age at adiposity rebound and thereby later risk of obesity. Milk and protein intake at 36months did not influence IGF-I but there was a negative association with intake of fat and saturated fat. The implications of this finding for development of obesity need further exploration.

U2 - 10.1016/j.ghir.2014.10.005

DO - 10.1016/j.ghir.2014.10.005

M3 - Journal article

C2 - 25466908

VL - 24

SP - 239

EP - 244

JO - Growth Hormone & I G F Research

JF - Growth Hormone & I G F Research

SN - 1096-6374

IS - 6

ER -

ID: 128607997