Forskning ved Københavns Universitet - Københavns Universitet

Forside

IMMUNOASSAYS FOR THE DETECTION OF UROKINASE RECEPTOR FORMS

Publikation: Patent

  • Timo Piironen (Opfinder)
  • Gunilla Hoeyer-Hansen, (Opfinder)
  • Nils Bruenner, (Opfinder)
  • Ploug, Michael (Opfinder)
  • Karin List (Opfinder)
  • Birgitte Laursen, (Opfinder)
  • Keld Danoe, (Opfinder)
  • Hans Liljas, (Opfinder)
  • Alexander Haese (Opfinder)
  • Huland Hartwig, (Opfinder)
  • Magnus Toernblom, (Opfinder)
  • Ove Gustafsson, (Opfinder)

The present invention relates to the design of three novel monoclonal uPAR sandwich assays for the specific detection of 1) full-length intact uPAR, 2) full-length intact uPAR and domain 2+3 fragment, and 3) domain 1 fragment of uPAR. The invention further relates to a method combining the detected amounts of uPAR forms in a sample with data indicative of the presence of the cancer disease. The method can be used for staging, prognosis or diagnosis of prostate cancer. Two novel monoclonal antibodies and a kit and immunoassays for detecting at least one uPAR form(s) are also described in the present invention.

OriginalsprogEngelsk
IPCG06F 19/ 20 A N
PatentnummerWO2004099780
LandDanmark
Prioritetsdato06/05/2003
PrioritetsnummerDK20030000676
StatusUdgivet - 18 nov. 2004

ID: 178221550