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Immunohistochemical localisation and developmental aspects of epidermal growth factor in the rat

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The tissue localisation and time of first appearance of Epidermal Growth Factor (EGF) in the developing rat were investigated by means of immunohistochemistry, radioimmunoassay and radioreceptor assay. In this study we were able to show, that EGF appears prenatally in the lung and the kidney from gestational day 19. Postnatally EGF was found also in the gastrointestinal tract, first in Brunner's glands of the duodenum (at birth), next in the Paneth cells (day 7), and finally in the submandibular glands (day 25). The immunohistochemical and radioreceptor results are consistent, whereas the radioimmunoassay detects EGF later and in smaller quantities, than does the radioreceptor assay. These differences will be discussed.

OriginalsprogEngelsk
TidsskriftHistochemistry
Vol/bind89
Udgave nummer4
Sider (fra-til)351-356
Antal sider6
ISSN0301-5564
DOI
StatusUdgivet - 1 jul. 1988

ID: 199324673