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Immunologic mapping of glycomes: implications for cancer diagnosis and therapy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Dapeng Zhou
  • Steven B Levery
  • Fong-Fu Hsu
  • Peng G Wang
  • Susann Teneberg
  • Igor C Almeida
  • Yunsen Li
  • Huaxi Xu
  • Lai-Xi Wang
  • Chengfeng Xia
  • Nuhad K Ibrahim
  • Katja Michael
Cancer associated glycoconjugates are important biomarkers, as exemplified by globo-H, CA125, CA15.3 and CA27.29. However, the exact chemical structures of many such biomarkers remain unknown because of technological limitations. In this article, we propose the "immunologic mapping" of cancer glycomes based on specific immune recognition of glycan structures, which can be hypothesized theoretically, produced chemically, and examined biologically by immuno-assays. Immunologic mapping of glycans not only provides a unique perspective on cancer glycomes, but also may lead to the invention of powerful reagents for diagnosis and therapy.
OriginalsprogEngelsk
TidsskriftFrontiers in Bioscience (Scholar Edition)
Vol/bind3
Sider (fra-til)1520-32
Antal sider13
ISSN1945-0516
StatusUdgivet - 1 jun. 2011

ID: 33752055