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Impact of the NCAM derived mimetic peptide plannexin on the acute cellular consequences of a status epilepticus

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Christina Zellinger
  • Martin Hadamitzky
  • Elisabeth Bock
  • Vladimir Berezin
  • Heidrun Potschka
Plannexin represents a NCAM-derived peptide mimicking trans-homophilic NCAM interaction, which proved to exert neuroprotective effects in vitro. The effect of plannexin was evaluated in a rat status epilepticus model. As expected, prolonged seizure activity resulted in a pronounced cell loss in hippocampal subregions. The comparison between the vehicle- and plannexin-treated animals with status epilepticus did not reveal neuroprotective effects of plannexin on mature neurons. However, treatment with plannexin partially prevented the reduction in the number of doublecortin-labeled neuronal progenitor cells, which was evident 48h following status epilepticus. In conclusion, the data might give first evidence that plannexin can protect immature neurons in vivo. Future studies are necessary to evaluate whether disease-modifying or preventive effects are observed in models of epileptogenesis.
OriginalsprogEngelsk
TidsskriftNeuroscience Letters
Vol/bind501
Udgave nummer3
Sider (fra-til)173-178
Antal sider6
ISSN0304-3940
DOI
StatusUdgivet - 2011

ID: 40354698