Forskning ved Københavns Universitet - Københavns Universitet

Forside

Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Brian Lawrence Odlaug
  • Samuel R Chamberlain
  • Katie L Derbyshire
  • Eric W Leppink
  • Jon E Grant

Trichotillomania is characterized by repetitive pulling out of one's own hair. Impaired response inhibition has been identified in patients with trichotillomania, along with gray matter density changes in distributed neural regions including frontal cortex. The objective of this study was to evaluate impaired response inhibition and abnormal cortical morphology as candidate endophenotypes for the disorder. Subjects with trichotillomania (N = 12), unaffected first-degree relatives of these patients (N = 10), and healthy controls (N = 14), completed the Stop Signal Task (SST), a measure of response inhibition, and structural magnetic resonance imaging scans. Group differences in SST performance and cortical thickness were explored using permutation testing. Groups differed significantly in response inhibition, with patients demonstrating impaired performance versus controls, and relatives occupying an intermediate position. Permutation cluster analysis revealed significant excesses of cortical thickness in patients and their relatives compared to controls, in right inferior/middle frontal gyri (Brodmann Area, BA 47 & 11), right lingual gyrus (BA 18), left superior temporal cortex (BA 21), and left precuneus (BA 7). No significant differences emerged between groups for striatum or cerebellar volumes. Impaired response inhibition and an excess of cortical thickness in neural regions germane to inhibitory control, and action monitoring, represent vulnerability markers for trichotillomania. Future work should explore genetic and environmental associations with these biological markers.

OriginalsprogEngelsk
TidsskriftJournal of Psychiatric Research
Vol/bind59
Sider (fra-til)167-73
Antal sider7
ISSN0022-3956
DOI
StatusUdgivet - dec. 2014

ID: 137509685