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Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania

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Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania. / Odlaug, Brian Lawrence; Chamberlain, Samuel R; Derbyshire, Katie L; Leppink, Eric W; Grant, Jon E.

I: Journal of Psychiatric Research, Bind 59, 12.2014, s. 167-73.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Odlaug, BL, Chamberlain, SR, Derbyshire, KL, Leppink, EW & Grant, JE 2014, 'Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania', Journal of Psychiatric Research, bind 59, s. 167-73. https://doi.org/10.1016/j.jpsychires.2014.08.010

APA

Odlaug, B. L., Chamberlain, S. R., Derbyshire, K. L., Leppink, E. W., & Grant, J. E. (2014). Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania. Journal of Psychiatric Research, 59, 167-73. https://doi.org/10.1016/j.jpsychires.2014.08.010

Vancouver

Odlaug BL, Chamberlain SR, Derbyshire KL, Leppink EW, Grant JE. Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania. Journal of Psychiatric Research. 2014 dec;59:167-73. https://doi.org/10.1016/j.jpsychires.2014.08.010

Author

Odlaug, Brian Lawrence ; Chamberlain, Samuel R ; Derbyshire, Katie L ; Leppink, Eric W ; Grant, Jon E. / Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania. I: Journal of Psychiatric Research. 2014 ; Bind 59. s. 167-73.

Bibtex

@article{dfb4345857c44ea88bd608e94591bffe,
title = "Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania",
abstract = "Trichotillomania is characterized by repetitive pulling out of one's own hair. Impaired response inhibition has been identified in patients with trichotillomania, along with gray matter density changes in distributed neural regions including frontal cortex. The objective of this study was to evaluate impaired response inhibition and abnormal cortical morphology as candidate endophenotypes for the disorder. Subjects with trichotillomania (N = 12), unaffected first-degree relatives of these patients (N = 10), and healthy controls (N = 14), completed the Stop Signal Task (SST), a measure of response inhibition, and structural magnetic resonance imaging scans. Group differences in SST performance and cortical thickness were explored using permutation testing. Groups differed significantly in response inhibition, with patients demonstrating impaired performance versus controls, and relatives occupying an intermediate position. Permutation cluster analysis revealed significant excesses of cortical thickness in patients and their relatives compared to controls, in right inferior/middle frontal gyri (Brodmann Area, BA 47 & 11), right lingual gyrus (BA 18), left superior temporal cortex (BA 21), and left precuneus (BA 7). No significant differences emerged between groups for striatum or cerebellar volumes. Impaired response inhibition and an excess of cortical thickness in neural regions germane to inhibitory control, and action monitoring, represent vulnerability markers for trichotillomania. Future work should explore genetic and environmental associations with these biological markers.",
author = "Odlaug, {Brian Lawrence} and Chamberlain, {Samuel R} and Derbyshire, {Katie L} and Leppink, {Eric W} and Grant, {Jon E}",
note = "Copyright {\textcopyright} 2014 Elsevier Ltd. All rights reserved.",
year = "2014",
month = dec,
doi = "10.1016/j.jpsychires.2014.08.010",
language = "English",
volume = "59",
pages = "167--73",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania

AU - Odlaug, Brian Lawrence

AU - Chamberlain, Samuel R

AU - Derbyshire, Katie L

AU - Leppink, Eric W

AU - Grant, Jon E

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.

PY - 2014/12

Y1 - 2014/12

N2 - Trichotillomania is characterized by repetitive pulling out of one's own hair. Impaired response inhibition has been identified in patients with trichotillomania, along with gray matter density changes in distributed neural regions including frontal cortex. The objective of this study was to evaluate impaired response inhibition and abnormal cortical morphology as candidate endophenotypes for the disorder. Subjects with trichotillomania (N = 12), unaffected first-degree relatives of these patients (N = 10), and healthy controls (N = 14), completed the Stop Signal Task (SST), a measure of response inhibition, and structural magnetic resonance imaging scans. Group differences in SST performance and cortical thickness were explored using permutation testing. Groups differed significantly in response inhibition, with patients demonstrating impaired performance versus controls, and relatives occupying an intermediate position. Permutation cluster analysis revealed significant excesses of cortical thickness in patients and their relatives compared to controls, in right inferior/middle frontal gyri (Brodmann Area, BA 47 & 11), right lingual gyrus (BA 18), left superior temporal cortex (BA 21), and left precuneus (BA 7). No significant differences emerged between groups for striatum or cerebellar volumes. Impaired response inhibition and an excess of cortical thickness in neural regions germane to inhibitory control, and action monitoring, represent vulnerability markers for trichotillomania. Future work should explore genetic and environmental associations with these biological markers.

AB - Trichotillomania is characterized by repetitive pulling out of one's own hair. Impaired response inhibition has been identified in patients with trichotillomania, along with gray matter density changes in distributed neural regions including frontal cortex. The objective of this study was to evaluate impaired response inhibition and abnormal cortical morphology as candidate endophenotypes for the disorder. Subjects with trichotillomania (N = 12), unaffected first-degree relatives of these patients (N = 10), and healthy controls (N = 14), completed the Stop Signal Task (SST), a measure of response inhibition, and structural magnetic resonance imaging scans. Group differences in SST performance and cortical thickness were explored using permutation testing. Groups differed significantly in response inhibition, with patients demonstrating impaired performance versus controls, and relatives occupying an intermediate position. Permutation cluster analysis revealed significant excesses of cortical thickness in patients and their relatives compared to controls, in right inferior/middle frontal gyri (Brodmann Area, BA 47 & 11), right lingual gyrus (BA 18), left superior temporal cortex (BA 21), and left precuneus (BA 7). No significant differences emerged between groups for striatum or cerebellar volumes. Impaired response inhibition and an excess of cortical thickness in neural regions germane to inhibitory control, and action monitoring, represent vulnerability markers for trichotillomania. Future work should explore genetic and environmental associations with these biological markers.

U2 - 10.1016/j.jpsychires.2014.08.010

DO - 10.1016/j.jpsychires.2014.08.010

M3 - Journal article

C2 - 25223951

VL - 59

SP - 167

EP - 173

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

ER -

ID: 137509685