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Impaired thermoregulatory function during dynamic exercise in multiple sclerosis

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Impaired thermoregulatory function during dynamic exercise in multiple sclerosis. / Allen, Dustin R; Huang, Mu; Morris, Nathan Bradley; Chaseling, Georgia K; Frohman, Elliot M; Jay, Ollie; Davis, Scott L.

I: Medicine and Science in Sports and Exercise, Bind 51, Nr. 3, 2019, s. 395-404.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Allen, DR, Huang, M, Morris, NB, Chaseling, GK, Frohman, EM, Jay, O & Davis, SL 2019, 'Impaired thermoregulatory function during dynamic exercise in multiple sclerosis', Medicine and Science in Sports and Exercise, bind 51, nr. 3, s. 395-404. https://doi.org/10.1249/MSS.0000000000001821

APA

Allen, D. R., Huang, M., Morris, N. B., Chaseling, G. K., Frohman, E. M., Jay, O., & Davis, S. L. (2019). Impaired thermoregulatory function during dynamic exercise in multiple sclerosis. Medicine and Science in Sports and Exercise, 51(3), 395-404. https://doi.org/10.1249/MSS.0000000000001821

Vancouver

Allen DR, Huang M, Morris NB, Chaseling GK, Frohman EM, Jay O o.a. Impaired thermoregulatory function during dynamic exercise in multiple sclerosis. Medicine and Science in Sports and Exercise. 2019;51(3):395-404. https://doi.org/10.1249/MSS.0000000000001821

Author

Allen, Dustin R ; Huang, Mu ; Morris, Nathan Bradley ; Chaseling, Georgia K ; Frohman, Elliot M ; Jay, Ollie ; Davis, Scott L. / Impaired thermoregulatory function during dynamic exercise in multiple sclerosis. I: Medicine and Science in Sports and Exercise. 2019 ; Bind 51, Nr. 3. s. 395-404.

Bibtex

@article{0cb2dca04748429db183518ebd9572cb,
title = "Impaired thermoregulatory function during dynamic exercise in multiple sclerosis",
abstract = "Introduction: Impairments in sudomotor function during passive whole-body heating have been reported in multiple sclerosis (MS), a demyelinating disease of the CNS that disrupts autonomic function. However, the capability of the thermoregulatory system to control body temperature during exercise has never been assessed in MS. Thus, the aim of the present study was to test the hypothesis that thermoregulatory function is impaired in MS patients compared with healthy controls (CON) exercising at similar rates of metabolic heat production. Methods: Sweating and skin blood flow responses were compared between 12 individuals diagnosed with relapsing-remitting MS (9 females, 3 males) and 12 sex-, age-, mass-, and BSA-matched CON during a single bout of cycling exercise (rate of metabolic heat production: ∼4.5 W·kg -1 ) for 60 min in a climate-controlled room (25°C, 30{\%} RH). Results: Individuals with MS exhibited an attenuated increase in cumulative whole-body sweat loss after 30 min (MS, 72 ± 51 g; CON, 104 ± 37 g; P = 0.04) and 60 min (MS, 209 ± 94 g; CON, 285 ± 62 g; P = 0.02), as well as lower sweating thermosensitivity (MS, 0.49 ± 0.26 mg·cm -2 ·min -1 ·°C -1 ; CON, 0.86 ± 0.30 mg·cm -2 ·min -1 ·°C -1 ; P = 0.049). Despite evidence for thermoregulatory dysfunction, there were no differences between MS and CON in esophageal or rectal temperatures at 30-or 60-min time points (P > 0.05). Cutaneous vasculature responses were also not different in MS compared with CON (P > 0.05). Conclusion: Taken together, MS blunts sweating responses during exercise while cutaneous vasculature responses are preserved. Altered mechanisms of body temperature regulation in persons with MS may lead to temporary worsening of disease symptoms and limit exercise tolerance under more thermally challenging conditions.",
keywords = "Autonomic dysfunction, Physical activity, Skin blood flow, Sweat rate, Thermosensitivity",
author = "Allen, {Dustin R} and Mu Huang and Morris, {Nathan Bradley} and Chaseling, {Georgia K} and Frohman, {Elliot M} and Ollie Jay and Davis, {Scott L}",
note = "(Ekstern)",
year = "2019",
doi = "10.1249/MSS.0000000000001821",
language = "English",
volume = "51",
pages = "395--404",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - Impaired thermoregulatory function during dynamic exercise in multiple sclerosis

AU - Allen, Dustin R

AU - Huang, Mu

AU - Morris, Nathan Bradley

AU - Chaseling, Georgia K

AU - Frohman, Elliot M

AU - Jay, Ollie

AU - Davis, Scott L

N1 - (Ekstern)

PY - 2019

Y1 - 2019

N2 - Introduction: Impairments in sudomotor function during passive whole-body heating have been reported in multiple sclerosis (MS), a demyelinating disease of the CNS that disrupts autonomic function. However, the capability of the thermoregulatory system to control body temperature during exercise has never been assessed in MS. Thus, the aim of the present study was to test the hypothesis that thermoregulatory function is impaired in MS patients compared with healthy controls (CON) exercising at similar rates of metabolic heat production. Methods: Sweating and skin blood flow responses were compared between 12 individuals diagnosed with relapsing-remitting MS (9 females, 3 males) and 12 sex-, age-, mass-, and BSA-matched CON during a single bout of cycling exercise (rate of metabolic heat production: ∼4.5 W·kg -1 ) for 60 min in a climate-controlled room (25°C, 30% RH). Results: Individuals with MS exhibited an attenuated increase in cumulative whole-body sweat loss after 30 min (MS, 72 ± 51 g; CON, 104 ± 37 g; P = 0.04) and 60 min (MS, 209 ± 94 g; CON, 285 ± 62 g; P = 0.02), as well as lower sweating thermosensitivity (MS, 0.49 ± 0.26 mg·cm -2 ·min -1 ·°C -1 ; CON, 0.86 ± 0.30 mg·cm -2 ·min -1 ·°C -1 ; P = 0.049). Despite evidence for thermoregulatory dysfunction, there were no differences between MS and CON in esophageal or rectal temperatures at 30-or 60-min time points (P > 0.05). Cutaneous vasculature responses were also not different in MS compared with CON (P > 0.05). Conclusion: Taken together, MS blunts sweating responses during exercise while cutaneous vasculature responses are preserved. Altered mechanisms of body temperature regulation in persons with MS may lead to temporary worsening of disease symptoms and limit exercise tolerance under more thermally challenging conditions.

AB - Introduction: Impairments in sudomotor function during passive whole-body heating have been reported in multiple sclerosis (MS), a demyelinating disease of the CNS that disrupts autonomic function. However, the capability of the thermoregulatory system to control body temperature during exercise has never been assessed in MS. Thus, the aim of the present study was to test the hypothesis that thermoregulatory function is impaired in MS patients compared with healthy controls (CON) exercising at similar rates of metabolic heat production. Methods: Sweating and skin blood flow responses were compared between 12 individuals diagnosed with relapsing-remitting MS (9 females, 3 males) and 12 sex-, age-, mass-, and BSA-matched CON during a single bout of cycling exercise (rate of metabolic heat production: ∼4.5 W·kg -1 ) for 60 min in a climate-controlled room (25°C, 30% RH). Results: Individuals with MS exhibited an attenuated increase in cumulative whole-body sweat loss after 30 min (MS, 72 ± 51 g; CON, 104 ± 37 g; P = 0.04) and 60 min (MS, 209 ± 94 g; CON, 285 ± 62 g; P = 0.02), as well as lower sweating thermosensitivity (MS, 0.49 ± 0.26 mg·cm -2 ·min -1 ·°C -1 ; CON, 0.86 ± 0.30 mg·cm -2 ·min -1 ·°C -1 ; P = 0.049). Despite evidence for thermoregulatory dysfunction, there were no differences between MS and CON in esophageal or rectal temperatures at 30-or 60-min time points (P > 0.05). Cutaneous vasculature responses were also not different in MS compared with CON (P > 0.05). Conclusion: Taken together, MS blunts sweating responses during exercise while cutaneous vasculature responses are preserved. Altered mechanisms of body temperature regulation in persons with MS may lead to temporary worsening of disease symptoms and limit exercise tolerance under more thermally challenging conditions.

KW - Autonomic dysfunction

KW - Physical activity

KW - Skin blood flow

KW - Sweat rate

KW - Thermosensitivity

UR - http://www.scopus.com/inward/record.url?scp=85061672944&partnerID=8YFLogxK

U2 - 10.1249/MSS.0000000000001821

DO - 10.1249/MSS.0000000000001821

M3 - Journal article

C2 - 30779715

AN - SCOPUS:85061672944

VL - 51

SP - 395

EP - 404

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 3

ER -

ID: 241162572