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Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

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  • Sandra S Haenni
  • Matthias Altmeyer
  • Paul O Hassa
  • Taras Valovka
  • Monika Fey
  • Michael O Hottiger
The enzymes responsible for the synthesis of poly-ADP-ribose are named poly-ADP-ribose polymerases (PARP). PARP-2 is a nuclear protein, which regulates a variety of cellular functions that are mainly controlled by protein-protein interactions. A previously described non-conventional bipartite nuclear localization sequence (NLS) lies in the amino-terminal DNA binding domain of PARP-2 between amino acids 1-69; however, this targeting sequence has not been experimentally examined or validated.
OriginalsprogEngelsk
TidsskriftB M C Cell Biology
Vol/bind9
Sider (fra-til)39
ISSN1471-2121
DOI
StatusUdgivet - 2008
Eksternt udgivetJa

ID: 43224502