Forskning ved Københavns Universitet - Københavns Universitet

Forside

In vitro antimycobacterial and antilegionella activity of licochalcone A from Chinese licorice roots

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Alice Friis-Møller
  • Ming Chen
  • Kurt Fuursted
  • Søren Brøgger Christensen
  • Arsalan Kharazmi
Licochalcone A, extracted and purified from Chinese licorice roots, showed in vitro inhibitory effect on human pathogenic Mycobacteria species and Legionella species. M. tuberculosis, M. bovis and BCG were inhibited by < 20 mg/l licochalcone A, whereas all non- M. tuberculosis complex species were resistant to > 20 mg/l Legionella pneumophila (serogroups 1 - 7) and L. bozemanii, L. dumoffii, L. feelei, L. longbeacheae and L. wadsworthii were inhibited by licochalcone A 1 - 4 mg/l, whereas L. gormanii and L. micdadei were inhibited by licochalcone A 500 - 1000 mg/l. These data indicate that licochalcone A might be of interest as a new class of antibacterial drug in the treatment of severe lung-infections.
OriginalsprogEngelsk
TidsskriftPlanta Medica
Vol/bind68
Udgave nummer5
Sider (fra-til)416-419
Antal sider4
ISSN0032-0943
DOI
StatusUdgivet - 2002

ID: 34149919