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Increased beta rhythm as an indicator of inhibitory mechanisms in tourette syndrome

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Valentina Niccolai
  • Hanneke van Dijk
  • Stephanie Franzkowiak
  • Jennifer Finis
  • Martin Südmeyer
  • Melanie Jonas
  • Götz Thomalla
  • Siebner, Hartwig Roman
  • Kirsten Müller-Vahl
  • Alexander Münchau
  • Alfons Schnitzler
  • Katja Biermann-Ruben

BACKGROUND: Inhibitory oscillatory mechanisms subserving tic compensation have been put forward in Tourette syndrome. Modulation of the beta rhythm (15-25 Hz) as the well-established oscillatory movement execution-inhibition indicator was tested during a cognitive-motor task in patients with Tourette syndrome.

METHODS: Performing a Go/NoGo task, 12 patients with Tourette syndrome and 12 matched controls were recorded using whole-head magnetoencephalography.

RESULTS: Compared to healthy participants, patients showed less beta suppression in the sensorimotor area and enhanced beta power in parieto-occipital brain regions contralaterally to the response hand. Average beta power and power gain correlated negatively with tic severity.

CONCLUSIONS: Increased motor inhibitory as well as visuomotor attentional processes are likely to subserve tic compensation. Correlational results suggest that stronger inhibitory compensation accompanies less tic severity. © 2016 International Parkinson and Movement Disorder Society.

OriginalsprogEngelsk
TidsskriftMovement disorders : official journal of the Movement Disorder Society
Vol/bind31
Udgave nummer3
Sider (fra-til)384-392
Antal sider9
ISSN0885-3185
DOI
StatusUdgivet - mar. 2016

ID: 161182708