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Increased muscle glucose uptake during contractions: no need for insulin

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Increased muscle glucose uptake during contractions : no need for insulin. / Ploug, Thorkil; Galbo, Henrik; Richter, Erik.

I: American Journal of Physiology: Endocrinology and Metabolism, Bind 247, Nr. 6, 12.1984, s. E726-731.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Ploug, T, Galbo, H & Richter, E 1984, 'Increased muscle glucose uptake during contractions: no need for insulin', American Journal of Physiology: Endocrinology and Metabolism, bind 247, nr. 6, s. E726-731.

APA

Ploug, T., Galbo, H., & Richter, E. (1984). Increased muscle glucose uptake during contractions: no need for insulin. American Journal of Physiology: Endocrinology and Metabolism, 247(6), E726-731.

Vancouver

Ploug T, Galbo H, Richter E. Increased muscle glucose uptake during contractions: no need for insulin. American Journal of Physiology: Endocrinology and Metabolism. 1984 dec;247(6):E726-731.

Author

Ploug, Thorkil ; Galbo, Henrik ; Richter, Erik. / Increased muscle glucose uptake during contractions : no need for insulin. I: American Journal of Physiology: Endocrinology and Metabolism. 1984 ; Bind 247, Nr. 6. s. E726-731.

Bibtex

@article{e8dfd95f87474078b8b4303e32953d15,
title = "Increased muscle glucose uptake during contractions: no need for insulin",
abstract = "We reinvestigated the prevailing concept that muscle contractions only elicit increased muscle glucose uptake in the presence of a so-called {"}permissive{"} concentration of insulin (Berger et al., Biochem. J. 146: 231-238, 1975; Vranic and Berger, Diabetes 28: 147-163, 1979). Hindquarters from rats in severe ketoacidosis were perfused with a perfusate containing insulin antiserum. After 60 min perfusion, electrical stimulation increased glucose uptake of the contracting muscles fivefold. Also, subsequent contractions increased glucose uptake in hindquarters from nondiabetic rats perfused for 1.5 h in the presence of antiserum. 3-O-methylglucose uptake was increased markedly by contractions in fast-twitch red and white fibers that were severely glycogen depleted but not in slow-twitch red fibers that were not glycogen depleted. In hindquarters from ketoacidotic rats perfused exactly as by Berger et al., 3-O-methylglucose uptake increased during contractions and glucose uptake was negative at rest and zero during contractions. An increase in muscle transport and uptake of glucose during contractions does not require the presence of insulin. Furthermore, glucose transport in contracting muscle may only increase if glycogen is depleted.",
keywords = "3-O-Methylglucose, Animals, Diabetes Mellitus, Experimental, Electric Stimulation, Glucose, Hindlimb, Immune Sera, Insulin, Male, Methylglucosides, Muscle Contraction, Muscles, Oxygen Consumption, Perfusion, Rats",
author = "Thorkil Ploug and Henrik Galbo and Erik Richter",
year = "1984",
month = "12",
language = "English",
volume = "247",
pages = "E726--731",
journal = "American Journal of Physiology: Endocrinology and Metabolism",
issn = "0193-1849",
publisher = "American Physiological Society",
number = "6",

}

RIS

TY - JOUR

T1 - Increased muscle glucose uptake during contractions

T2 - no need for insulin

AU - Ploug, Thorkil

AU - Galbo, Henrik

AU - Richter, Erik

PY - 1984/12

Y1 - 1984/12

N2 - We reinvestigated the prevailing concept that muscle contractions only elicit increased muscle glucose uptake in the presence of a so-called "permissive" concentration of insulin (Berger et al., Biochem. J. 146: 231-238, 1975; Vranic and Berger, Diabetes 28: 147-163, 1979). Hindquarters from rats in severe ketoacidosis were perfused with a perfusate containing insulin antiserum. After 60 min perfusion, electrical stimulation increased glucose uptake of the contracting muscles fivefold. Also, subsequent contractions increased glucose uptake in hindquarters from nondiabetic rats perfused for 1.5 h in the presence of antiserum. 3-O-methylglucose uptake was increased markedly by contractions in fast-twitch red and white fibers that were severely glycogen depleted but not in slow-twitch red fibers that were not glycogen depleted. In hindquarters from ketoacidotic rats perfused exactly as by Berger et al., 3-O-methylglucose uptake increased during contractions and glucose uptake was negative at rest and zero during contractions. An increase in muscle transport and uptake of glucose during contractions does not require the presence of insulin. Furthermore, glucose transport in contracting muscle may only increase if glycogen is depleted.

AB - We reinvestigated the prevailing concept that muscle contractions only elicit increased muscle glucose uptake in the presence of a so-called "permissive" concentration of insulin (Berger et al., Biochem. J. 146: 231-238, 1975; Vranic and Berger, Diabetes 28: 147-163, 1979). Hindquarters from rats in severe ketoacidosis were perfused with a perfusate containing insulin antiserum. After 60 min perfusion, electrical stimulation increased glucose uptake of the contracting muscles fivefold. Also, subsequent contractions increased glucose uptake in hindquarters from nondiabetic rats perfused for 1.5 h in the presence of antiserum. 3-O-methylglucose uptake was increased markedly by contractions in fast-twitch red and white fibers that were severely glycogen depleted but not in slow-twitch red fibers that were not glycogen depleted. In hindquarters from ketoacidotic rats perfused exactly as by Berger et al., 3-O-methylglucose uptake increased during contractions and glucose uptake was negative at rest and zero during contractions. An increase in muscle transport and uptake of glucose during contractions does not require the presence of insulin. Furthermore, glucose transport in contracting muscle may only increase if glycogen is depleted.

KW - 3-O-Methylglucose

KW - Animals

KW - Diabetes Mellitus, Experimental

KW - Electric Stimulation

KW - Glucose

KW - Hindlimb

KW - Immune Sera

KW - Insulin

KW - Male

KW - Methylglucosides

KW - Muscle Contraction

KW - Muscles

KW - Oxygen Consumption

KW - Perfusion

KW - Rats

M3 - Journal article

C2 - 6391198

VL - 247

SP - E726-731

JO - American Journal of Physiology: Endocrinology and Metabolism

JF - American Journal of Physiology: Endocrinology and Metabolism

SN - 0193-1849

IS - 6

ER -

ID: 123666654