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Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy

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Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy), fragmentation of nocturnal sleep and sleep paralysis. The symptoms of the disease strongly correlate with a reduction in hypocretin levels in CSF and a reduction in hypocretin neurons in hypothalamus in post-mortem tissue. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are important for activity-dependent neuronal function and synaptic modulation and it is considered that these mechanisms are important in sleep regulation. We hypothesised that serum levels of these factors are altered in patients with narcolepsy compared to healthy controls without sleep disturbances. Polysomnography data was obtained and serum BDNF and NGF levels measured using ELISA, while hypocretin was measured using RIA. Serum BDNF levels were significantly higher in narcolepsy patients than in healthy controls (64.2±3.9ng/ml vs 47.3±2.6ng/ml, P
OriginalsprogEngelsk
TidsskriftNeuroscience Letters
Vol/bind544
Sider (fra-til)31-35
Antal sider5
ISSN0304-3940
DOI
StatusUdgivet - 7 jun. 2013

ID: 117978450