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Influence of mannan-binding lectin and MAp44 on outcome in comatose survivors of out-of-hospital cardiac arrest

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Influence of mannan-binding lectin and MAp44 on outcome in comatose survivors of out-of-hospital cardiac arrest. / Bro-Jeppesen, John; Kjaergaard, Jesper; Thiel, Steffen; Jensenius, Jens Christian; Bjerre, Mette; Wanscher, Michael; Christensen, Jeppe V.; Hassager, Christian.

I: Resuscitation, Bind 101, 2016, s. 27-34.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bro-Jeppesen, J, Kjaergaard, J, Thiel, S, Jensenius, JC, Bjerre, M, Wanscher, M, Christensen, JV & Hassager, C 2016, 'Influence of mannan-binding lectin and MAp44 on outcome in comatose survivors of out-of-hospital cardiac arrest', Resuscitation, bind 101, s. 27-34. https://doi.org/10.1016/j.resuscitation.2016.01.007

APA

Bro-Jeppesen, J., Kjaergaard, J., Thiel, S., Jensenius, J. C., Bjerre, M., Wanscher, M., Christensen, J. V., & Hassager, C. (2016). Influence of mannan-binding lectin and MAp44 on outcome in comatose survivors of out-of-hospital cardiac arrest. Resuscitation, 101, 27-34. https://doi.org/10.1016/j.resuscitation.2016.01.007

Vancouver

Bro-Jeppesen J, Kjaergaard J, Thiel S, Jensenius JC, Bjerre M, Wanscher M o.a. Influence of mannan-binding lectin and MAp44 on outcome in comatose survivors of out-of-hospital cardiac arrest. Resuscitation. 2016;101:27-34. https://doi.org/10.1016/j.resuscitation.2016.01.007

Author

Bro-Jeppesen, John ; Kjaergaard, Jesper ; Thiel, Steffen ; Jensenius, Jens Christian ; Bjerre, Mette ; Wanscher, Michael ; Christensen, Jeppe V. ; Hassager, Christian. / Influence of mannan-binding lectin and MAp44 on outcome in comatose survivors of out-of-hospital cardiac arrest. I: Resuscitation. 2016 ; Bind 101. s. 27-34.

Bibtex

@article{e609a90e73d747b3962969e42a4b0f14,
title = "Influence of mannan-binding lectin and MAp44 on outcome in comatose survivors of out-of-hospital cardiac arrest",
abstract = "Aim: The lectin complement pathway, initiated by mannan-binding-lectin (MBL) plays a role in tissue destruction following ischemia/reperfusion, and MBL deficiency has been associated with favorable outcome in stroke patients. MAp44 is produced in the heart and may theoretically function as an endogenous inhibitor of MBL-mediated activities. The aim of this study was to investigate the possible association between MBL deficiency, MAp44 levels and outcome in comatose survivors of out-of-hospital cardiac arrest (OHCA). Methods: In a single center post hoc analysis of the prospective multicenter randomized Target Temperature Management (TTM) trial, we measured MBL and MAp44 levels at baseline, 24, 48 and 72 h after OHCA in 169 consecutive patients randomly assigned to TTM at 33 °C or 36 °C for 24 h. Primary outcome was 30 days mortality and secondary outcome was favorable neurological outcome assessed by Cerebral Performance Category (CPC1-2) and modified Rankin Scale (mRS0-3) 180 days after OHCA. Results: Patients with MBL deficiency (defined as plasma levels ≤100 ng ml-1 at baseline) (n = 22) carried a 30-day mortality of 41% compared to 32% in MBL sufficient patient (n = 147), p = 0.55. Baseline MAp44 levels were not associated with mortality, p = 0.25. There was no significant difference in neurological outcome between the two MBL groups assessed by CPC (p = 0.69) and mRS (p = 0.91). In multivariable models, baseline MBL (OR = 1.0, p = 0.70), (OR = 1.5, p = 0.30) and MAp44 levels (OR = 1.0, p = 0.99), (OR = 1.6, p = 0.21) were not associated with favorable neurological outcome assessed by CPC and mRS, respectively. Conclusions: In comatose survivors after cardiac arrest, neither MBL deficiency nor levels of MBL and MAp44 were associated with mortality or neurological outcome.",
keywords = "Cardiac arrest, Complement, Hypothermia, Mannan-binding lectin, Post-cardiac arrest syndrome",
author = "John Bro-Jeppesen and Jesper Kjaergaard and Steffen Thiel and Jensenius, {Jens Christian} and Mette Bjerre and Michael Wanscher and Christensen, {Jeppe V.} and Christian Hassager",
year = "2016",
doi = "10.1016/j.resuscitation.2016.01.007",
language = "English",
volume = "101",
pages = "27--34",
journal = "Resuscitation",
issn = "0300-9572",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Influence of mannan-binding lectin and MAp44 on outcome in comatose survivors of out-of-hospital cardiac arrest

AU - Bro-Jeppesen, John

AU - Kjaergaard, Jesper

AU - Thiel, Steffen

AU - Jensenius, Jens Christian

AU - Bjerre, Mette

AU - Wanscher, Michael

AU - Christensen, Jeppe V.

AU - Hassager, Christian

PY - 2016

Y1 - 2016

N2 - Aim: The lectin complement pathway, initiated by mannan-binding-lectin (MBL) plays a role in tissue destruction following ischemia/reperfusion, and MBL deficiency has been associated with favorable outcome in stroke patients. MAp44 is produced in the heart and may theoretically function as an endogenous inhibitor of MBL-mediated activities. The aim of this study was to investigate the possible association between MBL deficiency, MAp44 levels and outcome in comatose survivors of out-of-hospital cardiac arrest (OHCA). Methods: In a single center post hoc analysis of the prospective multicenter randomized Target Temperature Management (TTM) trial, we measured MBL and MAp44 levels at baseline, 24, 48 and 72 h after OHCA in 169 consecutive patients randomly assigned to TTM at 33 °C or 36 °C for 24 h. Primary outcome was 30 days mortality and secondary outcome was favorable neurological outcome assessed by Cerebral Performance Category (CPC1-2) and modified Rankin Scale (mRS0-3) 180 days after OHCA. Results: Patients with MBL deficiency (defined as plasma levels ≤100 ng ml-1 at baseline) (n = 22) carried a 30-day mortality of 41% compared to 32% in MBL sufficient patient (n = 147), p = 0.55. Baseline MAp44 levels were not associated with mortality, p = 0.25. There was no significant difference in neurological outcome between the two MBL groups assessed by CPC (p = 0.69) and mRS (p = 0.91). In multivariable models, baseline MBL (OR = 1.0, p = 0.70), (OR = 1.5, p = 0.30) and MAp44 levels (OR = 1.0, p = 0.99), (OR = 1.6, p = 0.21) were not associated with favorable neurological outcome assessed by CPC and mRS, respectively. Conclusions: In comatose survivors after cardiac arrest, neither MBL deficiency nor levels of MBL and MAp44 were associated with mortality or neurological outcome.

AB - Aim: The lectin complement pathway, initiated by mannan-binding-lectin (MBL) plays a role in tissue destruction following ischemia/reperfusion, and MBL deficiency has been associated with favorable outcome in stroke patients. MAp44 is produced in the heart and may theoretically function as an endogenous inhibitor of MBL-mediated activities. The aim of this study was to investigate the possible association between MBL deficiency, MAp44 levels and outcome in comatose survivors of out-of-hospital cardiac arrest (OHCA). Methods: In a single center post hoc analysis of the prospective multicenter randomized Target Temperature Management (TTM) trial, we measured MBL and MAp44 levels at baseline, 24, 48 and 72 h after OHCA in 169 consecutive patients randomly assigned to TTM at 33 °C or 36 °C for 24 h. Primary outcome was 30 days mortality and secondary outcome was favorable neurological outcome assessed by Cerebral Performance Category (CPC1-2) and modified Rankin Scale (mRS0-3) 180 days after OHCA. Results: Patients with MBL deficiency (defined as plasma levels ≤100 ng ml-1 at baseline) (n = 22) carried a 30-day mortality of 41% compared to 32% in MBL sufficient patient (n = 147), p = 0.55. Baseline MAp44 levels were not associated with mortality, p = 0.25. There was no significant difference in neurological outcome between the two MBL groups assessed by CPC (p = 0.69) and mRS (p = 0.91). In multivariable models, baseline MBL (OR = 1.0, p = 0.70), (OR = 1.5, p = 0.30) and MAp44 levels (OR = 1.0, p = 0.99), (OR = 1.6, p = 0.21) were not associated with favorable neurological outcome assessed by CPC and mRS, respectively. Conclusions: In comatose survivors after cardiac arrest, neither MBL deficiency nor levels of MBL and MAp44 were associated with mortality or neurological outcome.

KW - Cardiac arrest

KW - Complement

KW - Hypothermia

KW - Mannan-binding lectin

KW - Post-cardiac arrest syndrome

U2 - 10.1016/j.resuscitation.2016.01.007

DO - 10.1016/j.resuscitation.2016.01.007

M3 - Journal article

C2 - 26826565

AN - SCOPUS:84960447897

VL - 101

SP - 27

EP - 34

JO - Resuscitation

JF - Resuscitation

SN - 0300-9572

ER -

ID: 179132996