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Insulin release by glucagon and secretin: studies with secretin-glucagon hybrids

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Standard

Insulin release by glucagon and secretin : studies with secretin-glucagon hybrids. / Kofod, Hans; Andreu, D; Thams, P; Merrifield, R B; Hedeskov, C J; Hansen, B; Lernmark, A.

I: American Journal of Physiology (Consolidated), Bind 254, Nr. 4 Pt 1, 04.1988, s. E454-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Kofod, H, Andreu, D, Thams, P, Merrifield, RB, Hedeskov, CJ, Hansen, B & Lernmark, A 1988, 'Insulin release by glucagon and secretin: studies with secretin-glucagon hybrids', American Journal of Physiology (Consolidated), bind 254, nr. 4 Pt 1, s. E454-8.

APA

Kofod, H., Andreu, D., Thams, P., Merrifield, R. B., Hedeskov, C. J., Hansen, B., & Lernmark, A. (1988). Insulin release by glucagon and secretin: studies with secretin-glucagon hybrids. American Journal of Physiology (Consolidated), 254(4 Pt 1), E454-8.

Vancouver

Kofod H, Andreu D, Thams P, Merrifield RB, Hedeskov CJ, Hansen B o.a. Insulin release by glucagon and secretin: studies with secretin-glucagon hybrids. American Journal of Physiology (Consolidated). 1988 apr;254(4 Pt 1):E454-8.

Author

Kofod, Hans ; Andreu, D ; Thams, P ; Merrifield, R B ; Hedeskov, C J ; Hansen, B ; Lernmark, A. / Insulin release by glucagon and secretin : studies with secretin-glucagon hybrids. I: American Journal of Physiology (Consolidated). 1988 ; Bind 254, Nr. 4 Pt 1. s. E454-8.

Bibtex

@article{2b6c1d7c9b9c43909a8ebbec7ea757d9,
title = "Insulin release by glucagon and secretin: studies with secretin-glucagon hybrids",
abstract = "Secretin and glucagon potentiate glucose-induced insulin release. We have compared the effects of secretin and glucagon with that of four hybrid molecules of the two hormones on insulin release and formation of cyclic AMP (cAMP) in isolated mouse pancreatic islets. All six peptides potentiated the release of insulin at 10 mM D-glucose, and their effects were indistinguishable with respect to the dynamics of release, dose-response relationship, and glucose dependency. However, measurements of cAMP accumulation in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (10(-4) M) showed that the fold increase compared with glucose alone had the following ranking order: secretin = [Tyr10, Tyr13]-secretin 1.6 less than [Tyr10, Tyr13, Trp25]secretin 1.8 less than glucagon 1.9 less than [Asp3, Glu9, Arg12]glucagon 2.3 = [Asp3, Glu9]glucagon. These results suggest that despite similar potentiating effects of secretin and glucagon on glucose-induced insulin release, their modes of action may be different.",
keywords = "Amino Acid Sequence, Animals, Cyclic AMP, Glucagon, Glucose, Insulin, Islets of Langerhans, Kinetics, Male, Mice, Mice, Inbred Strains, Secretin",
author = "Hans Kofod and D Andreu and P Thams and Merrifield, {R B} and Hedeskov, {C J} and B Hansen and A Lernmark",
year = "1988",
month = apr,
language = "English",
volume = "254",
pages = "E454--8",
journal = "American Journal of Physiology (Consolidated)",
issn = "0002-9513",
publisher = "American Physiological Society",
number = "4 Pt 1",

}

RIS

TY - JOUR

T1 - Insulin release by glucagon and secretin

T2 - studies with secretin-glucagon hybrids

AU - Kofod, Hans

AU - Andreu, D

AU - Thams, P

AU - Merrifield, R B

AU - Hedeskov, C J

AU - Hansen, B

AU - Lernmark, A

PY - 1988/4

Y1 - 1988/4

N2 - Secretin and glucagon potentiate glucose-induced insulin release. We have compared the effects of secretin and glucagon with that of four hybrid molecules of the two hormones on insulin release and formation of cyclic AMP (cAMP) in isolated mouse pancreatic islets. All six peptides potentiated the release of insulin at 10 mM D-glucose, and their effects were indistinguishable with respect to the dynamics of release, dose-response relationship, and glucose dependency. However, measurements of cAMP accumulation in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (10(-4) M) showed that the fold increase compared with glucose alone had the following ranking order: secretin = [Tyr10, Tyr13]-secretin 1.6 less than [Tyr10, Tyr13, Trp25]secretin 1.8 less than glucagon 1.9 less than [Asp3, Glu9, Arg12]glucagon 2.3 = [Asp3, Glu9]glucagon. These results suggest that despite similar potentiating effects of secretin and glucagon on glucose-induced insulin release, their modes of action may be different.

AB - Secretin and glucagon potentiate glucose-induced insulin release. We have compared the effects of secretin and glucagon with that of four hybrid molecules of the two hormones on insulin release and formation of cyclic AMP (cAMP) in isolated mouse pancreatic islets. All six peptides potentiated the release of insulin at 10 mM D-glucose, and their effects were indistinguishable with respect to the dynamics of release, dose-response relationship, and glucose dependency. However, measurements of cAMP accumulation in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (10(-4) M) showed that the fold increase compared with glucose alone had the following ranking order: secretin = [Tyr10, Tyr13]-secretin 1.6 less than [Tyr10, Tyr13, Trp25]secretin 1.8 less than glucagon 1.9 less than [Asp3, Glu9, Arg12]glucagon 2.3 = [Asp3, Glu9]glucagon. These results suggest that despite similar potentiating effects of secretin and glucagon on glucose-induced insulin release, their modes of action may be different.

KW - Amino Acid Sequence

KW - Animals

KW - Cyclic AMP

KW - Glucagon

KW - Glucose

KW - Insulin

KW - Islets of Langerhans

KW - Kinetics

KW - Male

KW - Mice

KW - Mice, Inbred Strains

KW - Secretin

M3 - Journal article

C2 - 2833112

VL - 254

SP - E454-8

JO - American Journal of Physiology (Consolidated)

JF - American Journal of Physiology (Consolidated)

SN - 0002-9513

IS - 4 Pt 1

ER -

ID: 45575183