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Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Benjamin Ole Wolthers
  • Pernille R. Mogensen
  • Thomas L. Frandsen
  • Jonas Abrahamsson
  • Mikael Behrendtz
  • Mats Heyman
  • Olli Lohi
  • Ulrika Norén-Nyström
  • Ellen Ruud
  • Schmiegelow, K.

Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7–9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.

OriginalsprogEngelsk
Artikelnummere27437
TidsskriftPediatric Blood & Cancer
Vol/bind66
Udgave nummer1
Antal sider4
ISSN1545-5009
DOI
StatusUdgivet - 2019

ID: 223451544