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Intense synaptic activity enhances temporal resolution in spinal motoneurons

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Standard

Intense synaptic activity enhances temporal resolution in spinal motoneurons. / Berg, Rune W; Ditlevsen, Susanne; Hounsgaard, Jørn Dybkjær.

I: PLoS ONE, Bind 3, Nr. 9, 2008, s. e3218.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Berg, RW, Ditlevsen, S & Hounsgaard, JD 2008, 'Intense synaptic activity enhances temporal resolution in spinal motoneurons', PLoS ONE, bind 3, nr. 9, s. e3218. https://doi.org/10.1371/journal.pone.0003218

APA

Berg, R. W., Ditlevsen, S., & Hounsgaard, J. D. (2008). Intense synaptic activity enhances temporal resolution in spinal motoneurons. PLoS ONE, 3(9), e3218. https://doi.org/10.1371/journal.pone.0003218

Vancouver

Berg RW, Ditlevsen S, Hounsgaard JD. Intense synaptic activity enhances temporal resolution in spinal motoneurons. PLoS ONE. 2008;3(9):e3218. https://doi.org/10.1371/journal.pone.0003218

Author

Berg, Rune W ; Ditlevsen, Susanne ; Hounsgaard, Jørn Dybkjær. / Intense synaptic activity enhances temporal resolution in spinal motoneurons. I: PLoS ONE. 2008 ; Bind 3, Nr. 9. s. e3218.

Bibtex

@article{d00b42c0a42f11ddb5e9000ea68e967b,
title = "Intense synaptic activity enhances temporal resolution in spinal motoneurons",
abstract = "In neurons, spike timing is determined by integration of synaptic potentials in delicate concert with intrinsic properties. Although the integration time is functionally crucial, it remains elusive during network activity. While mechanisms of rapid processing are well documented in sensory systems, agility in motor systems has received little attention. Here we analyze how intense synaptic activity affects integration time in spinal motoneurons during functional motor activity and report a 10-fold decrease. As a result, action potentials can only be predicted from the membrane potential within 10 ms of their occurrence and detected for less than 10 ms after their occurrence. Being shorter than the average inter-spike interval, the AHP has little effect on integration time and spike timing, which instead is entirely determined by fluctuations in membrane potential caused by the barrage of inhibitory and excitatory synaptic activity. By shortening the effective integration time, this intense synaptic input may serve to facilitate the generation of rapid changes in movements.",
keywords = "Action Potentials, Animals, Computer Simulation, Electric Conductivity, Electrophysiology, Membrane Potentials, Models, Statistical, Motor Activity, Motor Neurons, Neurons, Spinal Cord, Stochastic Processes, Synapses, Synaptic Potentials, Time Factors, Turtles",
author = "Berg, {Rune W} and Susanne Ditlevsen and Hounsgaard, {J{\o}rn Dybkj{\ae}r}",
note = "Paper id:: doi:10.1371/journal.pone.0003218",
year = "2008",
doi = "10.1371/journal.pone.0003218",
language = "English",
volume = "3",
pages = "e3218",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - Intense synaptic activity enhances temporal resolution in spinal motoneurons

AU - Berg, Rune W

AU - Ditlevsen, Susanne

AU - Hounsgaard, Jørn Dybkjær

N1 - Paper id:: doi:10.1371/journal.pone.0003218

PY - 2008

Y1 - 2008

N2 - In neurons, spike timing is determined by integration of synaptic potentials in delicate concert with intrinsic properties. Although the integration time is functionally crucial, it remains elusive during network activity. While mechanisms of rapid processing are well documented in sensory systems, agility in motor systems has received little attention. Here we analyze how intense synaptic activity affects integration time in spinal motoneurons during functional motor activity and report a 10-fold decrease. As a result, action potentials can only be predicted from the membrane potential within 10 ms of their occurrence and detected for less than 10 ms after their occurrence. Being shorter than the average inter-spike interval, the AHP has little effect on integration time and spike timing, which instead is entirely determined by fluctuations in membrane potential caused by the barrage of inhibitory and excitatory synaptic activity. By shortening the effective integration time, this intense synaptic input may serve to facilitate the generation of rapid changes in movements.

AB - In neurons, spike timing is determined by integration of synaptic potentials in delicate concert with intrinsic properties. Although the integration time is functionally crucial, it remains elusive during network activity. While mechanisms of rapid processing are well documented in sensory systems, agility in motor systems has received little attention. Here we analyze how intense synaptic activity affects integration time in spinal motoneurons during functional motor activity and report a 10-fold decrease. As a result, action potentials can only be predicted from the membrane potential within 10 ms of their occurrence and detected for less than 10 ms after their occurrence. Being shorter than the average inter-spike interval, the AHP has little effect on integration time and spike timing, which instead is entirely determined by fluctuations in membrane potential caused by the barrage of inhibitory and excitatory synaptic activity. By shortening the effective integration time, this intense synaptic input may serve to facilitate the generation of rapid changes in movements.

KW - Action Potentials

KW - Animals

KW - Computer Simulation

KW - Electric Conductivity

KW - Electrophysiology

KW - Membrane Potentials

KW - Models, Statistical

KW - Motor Activity

KW - Motor Neurons

KW - Neurons

KW - Spinal Cord

KW - Stochastic Processes

KW - Synapses

KW - Synaptic Potentials

KW - Time Factors

KW - Turtles

U2 - 10.1371/journal.pone.0003218

DO - 10.1371/journal.pone.0003218

M3 - Journal article

C2 - 18795101

VL - 3

SP - e3218

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 9

ER -

ID: 8237613