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Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Standard

Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair. / Bendix, Poul Martin; Simonsen, Adam Cohen; Florentsen, Christoffer D; Häger, Swantje Christin; Mularski, Anna; Zanjani, Ali Asghar Hakami; Moreno-Pescador, Guillermo; Klenow, Martin Berg; Sønder, Stine Lauritzen; Danielsen, Helena M; Arastoo, Mohammad Reza; Heitmann, Anne Sofie; Pandey, Mayank Prakash; Lund, Frederik Wendelboe; Dias, Catarina; Khandelia, Himanshu; Nylandsted, Jesper.

I: Cells, Bind 9, Nr. 4, 1029, 21.04.2020.

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Harvard

Bendix, PM, Simonsen, AC, Florentsen, CD, Häger, SC, Mularski, A, Zanjani, AAH, Moreno-Pescador, G, Klenow, MB, Sønder, SL, Danielsen, HM, Arastoo, MR, Heitmann, AS, Pandey, MP, Lund, FW, Dias, C, Khandelia, H & Nylandsted, J 2020, 'Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair', Cells, bind 9, nr. 4, 1029. https://doi.org/10.3390/cells9041029

APA

Bendix, P. M., Simonsen, A. C., Florentsen, C. D., Häger, S. C., Mularski, A., Zanjani, A. A. H., ... Nylandsted, J. (2020). Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair. Cells, 9(4), [1029]. https://doi.org/10.3390/cells9041029

Vancouver

Bendix PM, Simonsen AC, Florentsen CD, Häger SC, Mularski A, Zanjani AAH o.a. Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair. Cells. 2020 apr 21;9(4). 1029. https://doi.org/10.3390/cells9041029

Author

Bendix, Poul Martin ; Simonsen, Adam Cohen ; Florentsen, Christoffer D ; Häger, Swantje Christin ; Mularski, Anna ; Zanjani, Ali Asghar Hakami ; Moreno-Pescador, Guillermo ; Klenow, Martin Berg ; Sønder, Stine Lauritzen ; Danielsen, Helena M ; Arastoo, Mohammad Reza ; Heitmann, Anne Sofie ; Pandey, Mayank Prakash ; Lund, Frederik Wendelboe ; Dias, Catarina ; Khandelia, Himanshu ; Nylandsted, Jesper. / Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair. I: Cells. 2020 ; Bind 9, Nr. 4.

Bibtex

@article{108c956d987b47dc8a0b38c2ee7d6952,
title = "Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair",
abstract = "The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma membrane. To counteract plasma membrane injuries, eukaryotic cells have developed efficient repair tools that depend on Ca2+- and phospholipid-binding annexin proteins. Upon membrane damage, annexin family members are activated by a Ca2+ influx, enabling them to quickly bind at the damaged membrane and facilitate wound healing. Our recent studies, based on interdisciplinary research synergy across molecular cell biology, experimental membrane physics, and computational simulations show that annexins have additional biophysical functions in the repair response besides enabling membrane fusion. Annexins possess different membrane-shaping properties, allowing for a tailored response that involves rapid bending, constriction, and fusion of membrane edges for resealing. Moreover, some annexins have high affinity for highly curved membranes that appear at free edges near rupture sites, a property that might accelerate their recruitment for rapid repair. Here, we discuss the mechanisms of annexin-mediated membrane shaping and curvature sensing in the light of our interdisciplinary approach to study plasma membrane repair.",
author = "Bendix, {Poul Martin} and Simonsen, {Adam Cohen} and Florentsen, {Christoffer D} and H{\"a}ger, {Swantje Christin} and Anna Mularski and Zanjani, {Ali Asghar Hakami} and Guillermo Moreno-Pescador and Klenow, {Martin Berg} and S{\o}nder, {Stine Lauritzen} and Danielsen, {Helena M} and Arastoo, {Mohammad Reza} and Heitmann, {Anne Sofie} and Pandey, {Mayank Prakash} and Lund, {Frederik Wendelboe} and Catarina Dias and Himanshu Khandelia and Jesper Nylandsted",
year = "2020",
month = "4",
day = "21",
doi = "10.3390/cells9041029",
language = "English",
volume = "9",
journal = "Cells",
issn = "2073-4409",
publisher = "MDPI AG",
number = "4",

}

RIS

TY - JOUR

T1 - Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair

AU - Bendix, Poul Martin

AU - Simonsen, Adam Cohen

AU - Florentsen, Christoffer D

AU - Häger, Swantje Christin

AU - Mularski, Anna

AU - Zanjani, Ali Asghar Hakami

AU - Moreno-Pescador, Guillermo

AU - Klenow, Martin Berg

AU - Sønder, Stine Lauritzen

AU - Danielsen, Helena M

AU - Arastoo, Mohammad Reza

AU - Heitmann, Anne Sofie

AU - Pandey, Mayank Prakash

AU - Lund, Frederik Wendelboe

AU - Dias, Catarina

AU - Khandelia, Himanshu

AU - Nylandsted, Jesper

PY - 2020/4/21

Y1 - 2020/4/21

N2 - The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma membrane. To counteract plasma membrane injuries, eukaryotic cells have developed efficient repair tools that depend on Ca2+- and phospholipid-binding annexin proteins. Upon membrane damage, annexin family members are activated by a Ca2+ influx, enabling them to quickly bind at the damaged membrane and facilitate wound healing. Our recent studies, based on interdisciplinary research synergy across molecular cell biology, experimental membrane physics, and computational simulations show that annexins have additional biophysical functions in the repair response besides enabling membrane fusion. Annexins possess different membrane-shaping properties, allowing for a tailored response that involves rapid bending, constriction, and fusion of membrane edges for resealing. Moreover, some annexins have high affinity for highly curved membranes that appear at free edges near rupture sites, a property that might accelerate their recruitment for rapid repair. Here, we discuss the mechanisms of annexin-mediated membrane shaping and curvature sensing in the light of our interdisciplinary approach to study plasma membrane repair.

AB - The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma membrane. To counteract plasma membrane injuries, eukaryotic cells have developed efficient repair tools that depend on Ca2+- and phospholipid-binding annexin proteins. Upon membrane damage, annexin family members are activated by a Ca2+ influx, enabling them to quickly bind at the damaged membrane and facilitate wound healing. Our recent studies, based on interdisciplinary research synergy across molecular cell biology, experimental membrane physics, and computational simulations show that annexins have additional biophysical functions in the repair response besides enabling membrane fusion. Annexins possess different membrane-shaping properties, allowing for a tailored response that involves rapid bending, constriction, and fusion of membrane edges for resealing. Moreover, some annexins have high affinity for highly curved membranes that appear at free edges near rupture sites, a property that might accelerate their recruitment for rapid repair. Here, we discuss the mechanisms of annexin-mediated membrane shaping and curvature sensing in the light of our interdisciplinary approach to study plasma membrane repair.

U2 - 10.3390/cells9041029

DO - 10.3390/cells9041029

M3 - Review

C2 - 32326222

VL - 9

JO - Cells

JF - Cells

SN - 2073-4409

IS - 4

M1 - 1029

ER -

ID: 240142633