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Interferon-β treatment associated with a biochemical profile suggestive of acromegaly. A case report of a patient treated for multiple sclerosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Mikkel Andreassen
  • Jan Frystyk
  • Karen K Miller
  • Lars Ø Kristensen
We describe a 34-year-old female treated with IFN-ß for 8 years with a biochemical profile suggestive of acromegaly. The patient presented with elevated serum insulin-like growth factor-I (IGF-I) and insufficient suppression of growth hormone (GH) during oral glucose tolerance test (OGTT). There were no clinical features of acromegaly. A 5-day profile showed higher GH levels on the 3 days following IFN-ß injections. Total and bioactive IGF-I were also elevated but did not fluctuate. Four weeks off IFN-ß normalized suppression of GH during OGTT but did not reduce serum IGF-I or bioactive IGF-I. In conclusion, IFN-ß treatment mimicked acromegaly biochemically. The changes were partially reversible.
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clinical & Laboratory Investigation
Vol/bind70
Udgave nummer7
Sider (fra-til)519-22
Antal sider4
ISSN0036-5513
DOI
StatusUdgivet - 2010

ID: 40172372