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Interleukin-6 release from the human brain during prolonged exercise

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Interleukin-6 release from the human brain during prolonged exercise. / Nybo, Lars; Nielsen, Bodil; Pedersen, Bente Klarlund; Møller, Kirsten; Secher, Niels H.

I: Journal of Physiology, Bind 542, Nr. Pt3, 31.12.2002, s. 991-995.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Nybo, L, Nielsen, B, Pedersen, BK, Møller, K & Secher, NH 2002, 'Interleukin-6 release from the human brain during prolonged exercise', Journal of Physiology, bind 542, nr. Pt3, s. 991-995.

APA

Nybo, L., Nielsen, B., Pedersen, B. K., Møller, K., & Secher, N. H. (2002). Interleukin-6 release from the human brain during prolonged exercise. Journal of Physiology, 542(Pt3), 991-995.

Vancouver

Nybo L, Nielsen B, Pedersen BK, Møller K, Secher NH. Interleukin-6 release from the human brain during prolonged exercise. Journal of Physiology. 2002 dec 31;542(Pt3):991-995.

Author

Nybo, Lars ; Nielsen, Bodil ; Pedersen, Bente Klarlund ; Møller, Kirsten ; Secher, Niels H. / Interleukin-6 release from the human brain during prolonged exercise. I: Journal of Physiology. 2002 ; Bind 542, Nr. Pt3. s. 991-995.

Bibtex

@article{e496f41adbca47cbbe047468ad913503,
title = "Interleukin-6 release from the human brain during prolonged exercise",
abstract = "Interleukin (IL)-6 is a pleiotropic cytokine, which has a variety of physiological roles including functions within the central nervous system. Circulating IL-6 increases markedly during exercise, partly due to the release of IL-6 from the contracting skeletal muscles, and exercise-induced IL-6 may be linked with central fatigue, which is enhanced by hyperthermia. Exercise-induced IL-6 may also stimulate hepatic glycogenolysis, which is important during prolonged and repeated exercise. Thus, in a randomised order and separated by 60 min of rest, eight young male subjects completed two 60 min exercise bouts: one bout with a normal (38 degrees C) and the other with an elevated (39.5 degrees C) core temperature. The cerebral IL-6 response was determined on the basis of internal jugular venous to arterial IL-6 differences and global cerebral blood flow. There was no net release or uptake of IL-6 in the brain at rest or after 15 min of exercise, but a small release of IL-6 was observed after 60 min of exercise in the first bout (0.06 +/- 0.03 ng min(-1)). This release of IL-6 from the brain was five-fold greater at the end of the second bout (0.30 +/- 0.08 ng min(-1); P < 0.05) with no separate influence of hyperthermia. In conclusion, IL-6 is released from the brain during prolonged exercise in humans and it appears that the duration of the exercise rather than the increase in body temperature dictates the cerebral IL-6 response.",
author = "Lars Nybo and Bodil Nielsen and Pedersen, {Bente Klarlund} and Kirsten M{\o}ller and Secher, {Niels H.}",
year = "2002",
month = dec,
day = "31",
language = "English",
volume = "542",
pages = "991--995",
journal = "The Journal of Physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell",
number = "Pt3",

}

RIS

TY - JOUR

T1 - Interleukin-6 release from the human brain during prolonged exercise

AU - Nybo, Lars

AU - Nielsen, Bodil

AU - Pedersen, Bente Klarlund

AU - Møller, Kirsten

AU - Secher, Niels H.

PY - 2002/12/31

Y1 - 2002/12/31

N2 - Interleukin (IL)-6 is a pleiotropic cytokine, which has a variety of physiological roles including functions within the central nervous system. Circulating IL-6 increases markedly during exercise, partly due to the release of IL-6 from the contracting skeletal muscles, and exercise-induced IL-6 may be linked with central fatigue, which is enhanced by hyperthermia. Exercise-induced IL-6 may also stimulate hepatic glycogenolysis, which is important during prolonged and repeated exercise. Thus, in a randomised order and separated by 60 min of rest, eight young male subjects completed two 60 min exercise bouts: one bout with a normal (38 degrees C) and the other with an elevated (39.5 degrees C) core temperature. The cerebral IL-6 response was determined on the basis of internal jugular venous to arterial IL-6 differences and global cerebral blood flow. There was no net release or uptake of IL-6 in the brain at rest or after 15 min of exercise, but a small release of IL-6 was observed after 60 min of exercise in the first bout (0.06 +/- 0.03 ng min(-1)). This release of IL-6 from the brain was five-fold greater at the end of the second bout (0.30 +/- 0.08 ng min(-1); P < 0.05) with no separate influence of hyperthermia. In conclusion, IL-6 is released from the brain during prolonged exercise in humans and it appears that the duration of the exercise rather than the increase in body temperature dictates the cerebral IL-6 response.

AB - Interleukin (IL)-6 is a pleiotropic cytokine, which has a variety of physiological roles including functions within the central nervous system. Circulating IL-6 increases markedly during exercise, partly due to the release of IL-6 from the contracting skeletal muscles, and exercise-induced IL-6 may be linked with central fatigue, which is enhanced by hyperthermia. Exercise-induced IL-6 may also stimulate hepatic glycogenolysis, which is important during prolonged and repeated exercise. Thus, in a randomised order and separated by 60 min of rest, eight young male subjects completed two 60 min exercise bouts: one bout with a normal (38 degrees C) and the other with an elevated (39.5 degrees C) core temperature. The cerebral IL-6 response was determined on the basis of internal jugular venous to arterial IL-6 differences and global cerebral blood flow. There was no net release or uptake of IL-6 in the brain at rest or after 15 min of exercise, but a small release of IL-6 was observed after 60 min of exercise in the first bout (0.06 +/- 0.03 ng min(-1)). This release of IL-6 from the brain was five-fold greater at the end of the second bout (0.30 +/- 0.08 ng min(-1); P < 0.05) with no separate influence of hyperthermia. In conclusion, IL-6 is released from the brain during prolonged exercise in humans and it appears that the duration of the exercise rather than the increase in body temperature dictates the cerebral IL-6 response.

M3 - Journal article

VL - 542

SP - 991

EP - 995

JO - The Journal of Physiology

JF - The Journal of Physiology

SN - 0022-3751

IS - Pt3

ER -

ID: 162989398