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Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells

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  • Hélène Le Pabic
  • Annie L'Helgoualc'h
  • Alexandre Coutant
  • Wewer, Ulla M.
  • Georges Baffet
  • Bruno Clément
  • Nathalie Théret
In chronic liver injury, quiescent hepatic stellate cells change into proliferative myofibroblast-like cells, which are a main source of fibrosis. We have recently reported that these cells synthesize ADAM12, a disintegrin and metalloprotease whose expression is up-regulated by TGF-beta1 in liver cancers. Here, we studied the role of the serine/threonine p70S6 kinase (p70S6K) in regulating TGF-beta1-induced ADAM12 expression.
OriginalsprogEngelsk
TidsskriftJournal of Hepatology
Vol/bind43
Udgave nummer6
Sider (fra-til)1038-44
Antal sider7
ISSN0168-8278
DOI
StatusUdgivet - 1 dec. 2005

ID: 34325183