Forskning ved Københavns Universitet - Københavns Universitet

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Ion channels and transporters in the development of drug resistance in cancer cells

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Multi-drug resistance (MDR) to chemotherapy is the major challenge in the treatment of cancer. MDR can develop by numerous mechanisms including decreased drug uptake, increased drug efflux and the failure to undergo drug-induced apoptosis. Evasion of drug-induced apoptosis through modulation of ion transporters is the main focus of this paper and we demonstrate how pro-apoptotic ion channels are downregulated, while anti-apoptotic ion transporters are upregulated in MDR. We also discuss whether upregulation of ion transport proteins that are important for proliferation contribute to MDR. Finally, we discuss the possibility that the development of MDR involves sequential and localized upregulation of ion channels involved in proliferation and migration and a concomitant global and persistent downregulation of ion channels involved in apoptosis.
OriginalsprogEngelsk
TidsskriftPhilosophical Transactions of the Royal Society B: Biological Sciences
Vol/bind369
Udgave nummer1638
Antal sider9
ISSN0962-8436
DOI
StatusUdgivet - 2014

Bibliografisk note

Theme Issue "Ion channels, transporters and cancer"

ID: 103647778