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Ionic signalling in astroglia beyond calcium

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Astrocytes are homeostatic and protective cells of the central nervous system. Astroglial homeostatic responses are tightly coordinated with neuronal activity. Astrocytes maintain neuronal excitability through regulation of extracellular ion concentrations, as well as assisting and modulating synaptic transmission by uptake and catabolism of major neurotransmitters. Moreover, they support neuronal metabolism and detoxify ammonium and reactive oxygen species. Astroglial homeostatic actions are initiated and controlled by intercellular signalling of ions, including Ca 2+ , Na + , Cl , H + and possibly K + . This review summarises current knowledge on ionic signals mediated by the major monovalent ions, which occur in microdomains, as global events, or as propagating intercellular waves and thereby represent the substrate for astroglial excitability. (Figure presented.).

OriginalsprogEngelsk
TidsskriftThe Journal of Physiology
Vol/bind598
Udgave nummer9
Sider (fra-til)1655-1670
Antal sider16
ISSN0022-3751
DOI
StatusUdgivet - 2020

ID: 226261899