Forskning ved Københavns Universitet - Københavns Universitet

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IR spectroscopy together with multivariate data analysis as a process analytical tool for in-line monitoring of crystallization process and solid-state analysis of crystalline product

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Kati Pöllänen
  • Antti Häkkinen
  • Satu-Pia Reinikainen
  • Rantanen, Jukka
  • Milja Karjalainen
  • Marjatta Louhi-Kultanen
  • Lars Nyström

Crystalline product should exist in optimal polymorphic form. Robust and reliable method for polymorph characterization is of great importance. In this work, infra red (IR) spectroscopy is applied for monitoring of crystallization process in situ. The results show that attenuated total reflection Fourier transform infra red (ATR-FTIR) spectroscopy provides valuable information on process, which can be utilized for more controlled crystallization processes. Diffuse reflectance Fourier transform infra red (DRIFT-IR) is applied for polymorphic characterization of crystalline product using X-ray powder diffraction (XRPD) as a reference technique. In order to fully utilize DRIFT, the application of multivariate techniques are needed, e.g., multivariate statistical process control (MSPC), principal component analysis (PCA) and partial least squares (PLS). The results demonstrate that multivariate techniques provide the powerful tool for rapid evaluation of spectral data and also enable more reliable quantification of polymorphic composition of samples being mixtures of two or more polymorphs. This opens new perspectives for understanding crystallization processes and increases the level of safety within the manufacture of pharmaceutics.

OriginalsprogEngelsk
TidsskriftJournal of Pharmaceutical and Biomedical Analysis
Vol/bind38
Udgave nummer2
Sider (fra-til)275-84
Antal sider10
ISSN0731-7085
DOI
StatusUdgivet - 15 jun. 2005

    Forskningsområder

  • Algorithms, Crystallization, Least-Squares Analysis, Multivariate Analysis, Pharmaceutical Preparations, Spectrophotometry, Infrared, Spectroscopy, Fourier Transform Infrared, Technology, Pharmaceutical, X-Ray Diffraction

ID: 140622403