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Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso? / Cherif, Mariama K; Sanou, Guillaume S; Bougouma, Edith C; Diarra, Amidou; Ouédraogo, Alphonse; Dolo, Amagana; Troye-Blomberg, Marita; Cavanagh, David R; Theisen, Michael; Modiano, David; Sirima, Sodiomon B; Nebié, Issa.

I: Acta Tropica, Bind 142, 02.2015, s. 41-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Cherif, MK, Sanou, GS, Bougouma, EC, Diarra, A, Ouédraogo, A, Dolo, A, Troye-Blomberg, M, Cavanagh, DR, Theisen, M, Modiano, D, Sirima, SB & Nebié, I 2015, 'Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso?', Acta Tropica, bind 142, s. 41-6. https://doi.org/10.1016/j.actatropica.2014.09.019

APA

Cherif, M. K., Sanou, G. S., Bougouma, E. C., Diarra, A., Ouédraogo, A., Dolo, A., ... Nebié, I. (2015). Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso? Acta Tropica, 142, 41-6. https://doi.org/10.1016/j.actatropica.2014.09.019

Vancouver

Cherif MK, Sanou GS, Bougouma EC, Diarra A, Ouédraogo A, Dolo A o.a. Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso? Acta Tropica. 2015 feb;142:41-6. https://doi.org/10.1016/j.actatropica.2014.09.019

Author

Cherif, Mariama K ; Sanou, Guillaume S ; Bougouma, Edith C ; Diarra, Amidou ; Ouédraogo, Alphonse ; Dolo, Amagana ; Troye-Blomberg, Marita ; Cavanagh, David R ; Theisen, Michael ; Modiano, David ; Sirima, Sodiomon B ; Nebié, Issa. / Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso?. I: Acta Tropica. 2015 ; Bind 142. s. 41-6.

Bibtex

@article{3ab5619bfaf94f6f8ba58253790a3e96,
title = "Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso?",
abstract = "In the present study, the influences of FcγRIIA polymorphism on susceptibility to malaria and antibody responses to Plasmodium falciparum antigens were analyzed in children. We recruited 96 healthy children between 3 and 10 years at the beginning of the high transmission season and we followed up for 5 months through the high transmission season to assess the parasitological, immunological and genetic endpoints in relation to clinical malaria status. There was a similar distribution of homozygous and heterozygous individuals carrying the FcγRIIA-131R/R and FcγRIIA-131R/H allele, whereas the number of FcγRIIA-131H/H homozygous individuals was lower. P. falciparum infection frequency was not associated with the FcγRIIa-131R/H polymorphism. Only IgG antibody responses to GLURP R0 showed a significant association between antibody levels and FcγRIIA polymorphism (p=0.02). IgG levels to MSP2a were significantly higher in children who did not experience any clinical malaria episode compared to those who experienced at least one malaria episode (p=0.019). Cytophilic and non-cytophylic IgG subclass levels were higher in children without malaria than those who experienced at least one malaria episode. This difference was statistically significant for IgG1 to MSP3 (p=0.003) and to MSP2a (p=0.006); IgG3 to MSP2a (p=0.007) and to GLURP R0 (p=0.044); IgG2 to MSP2b (p=0.007) and IgG4 to MSP3 (p=0.051) and to MSP2a (p=0.049). In this study, homozygous carriers of the FcγRIIA-131R/R allele had higher malaria-specific antibody levels compare to the heterozygous carriers FcγRIIA-131R/H alleles and to homozygous carriers of FcγRIIA-131H/H alleles. The pre-existing antibodies responses were related to a reduced subsequent risk of clinical malaria.",
author = "Cherif, {Mariama K} and Sanou, {Guillaume S} and Bougouma, {Edith C} and Amidou Diarra and Alphonse Ou{\'e}draogo and Amagana Dolo and Marita Troye-Blomberg and Cavanagh, {David R} and Michael Theisen and David Modiano and Sirima, {Sodiomon B} and Issa Nebi{\'e}",
note = "Copyright {\circledC} 2014 Elsevier B.V. All rights reserved.",
year = "2015",
month = "2",
doi = "10.1016/j.actatropica.2014.09.019",
language = "English",
volume = "142",
pages = "41--6",
journal = "Acta Tropica",
issn = "0001-706X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Is Fc gamma receptor IIA (FcγRIIA) polymorphism associated with clinical malaria and Plasmodium falciparum specific antibody levels in children from Burkina Faso?

AU - Cherif, Mariama K

AU - Sanou, Guillaume S

AU - Bougouma, Edith C

AU - Diarra, Amidou

AU - Ouédraogo, Alphonse

AU - Dolo, Amagana

AU - Troye-Blomberg, Marita

AU - Cavanagh, David R

AU - Theisen, Michael

AU - Modiano, David

AU - Sirima, Sodiomon B

AU - Nebié, Issa

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2015/2

Y1 - 2015/2

N2 - In the present study, the influences of FcγRIIA polymorphism on susceptibility to malaria and antibody responses to Plasmodium falciparum antigens were analyzed in children. We recruited 96 healthy children between 3 and 10 years at the beginning of the high transmission season and we followed up for 5 months through the high transmission season to assess the parasitological, immunological and genetic endpoints in relation to clinical malaria status. There was a similar distribution of homozygous and heterozygous individuals carrying the FcγRIIA-131R/R and FcγRIIA-131R/H allele, whereas the number of FcγRIIA-131H/H homozygous individuals was lower. P. falciparum infection frequency was not associated with the FcγRIIa-131R/H polymorphism. Only IgG antibody responses to GLURP R0 showed a significant association between antibody levels and FcγRIIA polymorphism (p=0.02). IgG levels to MSP2a were significantly higher in children who did not experience any clinical malaria episode compared to those who experienced at least one malaria episode (p=0.019). Cytophilic and non-cytophylic IgG subclass levels were higher in children without malaria than those who experienced at least one malaria episode. This difference was statistically significant for IgG1 to MSP3 (p=0.003) and to MSP2a (p=0.006); IgG3 to MSP2a (p=0.007) and to GLURP R0 (p=0.044); IgG2 to MSP2b (p=0.007) and IgG4 to MSP3 (p=0.051) and to MSP2a (p=0.049). In this study, homozygous carriers of the FcγRIIA-131R/R allele had higher malaria-specific antibody levels compare to the heterozygous carriers FcγRIIA-131R/H alleles and to homozygous carriers of FcγRIIA-131H/H alleles. The pre-existing antibodies responses were related to a reduced subsequent risk of clinical malaria.

AB - In the present study, the influences of FcγRIIA polymorphism on susceptibility to malaria and antibody responses to Plasmodium falciparum antigens were analyzed in children. We recruited 96 healthy children between 3 and 10 years at the beginning of the high transmission season and we followed up for 5 months through the high transmission season to assess the parasitological, immunological and genetic endpoints in relation to clinical malaria status. There was a similar distribution of homozygous and heterozygous individuals carrying the FcγRIIA-131R/R and FcγRIIA-131R/H allele, whereas the number of FcγRIIA-131H/H homozygous individuals was lower. P. falciparum infection frequency was not associated with the FcγRIIa-131R/H polymorphism. Only IgG antibody responses to GLURP R0 showed a significant association between antibody levels and FcγRIIA polymorphism (p=0.02). IgG levels to MSP2a were significantly higher in children who did not experience any clinical malaria episode compared to those who experienced at least one malaria episode (p=0.019). Cytophilic and non-cytophylic IgG subclass levels were higher in children without malaria than those who experienced at least one malaria episode. This difference was statistically significant for IgG1 to MSP3 (p=0.003) and to MSP2a (p=0.006); IgG3 to MSP2a (p=0.007) and to GLURP R0 (p=0.044); IgG2 to MSP2b (p=0.007) and IgG4 to MSP3 (p=0.051) and to MSP2a (p=0.049). In this study, homozygous carriers of the FcγRIIA-131R/R allele had higher malaria-specific antibody levels compare to the heterozygous carriers FcγRIIA-131R/H alleles and to homozygous carriers of FcγRIIA-131H/H alleles. The pre-existing antibodies responses were related to a reduced subsequent risk of clinical malaria.

U2 - 10.1016/j.actatropica.2014.09.019

DO - 10.1016/j.actatropica.2014.09.019

M3 - Journal article

C2 - 25447268

VL - 142

SP - 41

EP - 46

JO - Acta Tropica

JF - Acta Tropica

SN - 0001-706X

ER -

ID: 130282906