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Lack of immunomodulating effect of disulfiram on HIV positive patients

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Disulfiram (Antabuse (R)) is metabolized to two molecules of diethyldithiocarbamate, which has been reported to be an immunomodulating agent. In a double blind trial, 15 HIV antibody positive homosexual men were given daily doses of 100 mg or 400 mg of disulfiram or placebo, for 4 weeks. All had a CD4-count below 500 X 10(6)/l and/or a pokeweed mitogen response in a lymphocyte proliferation assay less than 50% of normal controls. None suffered from opportunistic infections. No significant effect of disulfiram on immunological, haematological, biochemical or clinical variables was observed in this short-term trial.
OriginalsprogEngelsk
TidsskriftInternational Journal of Immunopharmacology
Vol/bind12
Udgave nummer2
Sider (fra-til)145-7
Antal sider3
ISSN0192-0561
StatusUdgivet - 1 jan. 1990

ID: 33891068