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Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery

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The present study examined if a marked reduction in oxygen delivery, unlike findings with moderate intensity exercise, would slow leg oxygen uptake (VO2) kinetics during intense exercise (86±3% of incremental test peak power). Seven healthy males (26±1 years, mean±SEM) performed one-legged knee-extensor exercise (60±3 W) for 4 min in a control setting (CON) and with arterial infusion of L-NMMA and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50% lower (P
OriginalsprogEngelsk
TidsskriftAmerican Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Vol/bind305
Udgave nummer3
Sider (fra-til)R313-R321
Antal sider9
ISSN0363-6119
DOI
StatusUdgivet - 2013

Bibliografisk note

CURIS 2013 NEXS 124

ID: 46386153