Forskning ved Københavns Universitet - Københavns Universitet

Forside

Ligand-receptor interactions and membrane structure investigated by AFM and time-resolved fluorescence microscopy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

The atomic force microscope (AFM) and the associated dynamic force spectroscopy technique have been exploited to quantitatively assess the interaction between proteins and their binding to specific ligands and membrane surfaces. In particular, we have studied the specific interaction between lung surfactant protein D and various carbohydrates. In addition, we have used scanning AFM and time-resolved fluorescence microscopy to image the lateral structure of different lipid bilayers and their morphological changes as a function of time. The various systems studied illustrate the potential of modern AFM techniques for application to biomedical research, specifically within immunology and liposome-based drug delivery.

OriginalsprogEngelsk
TidsskriftJournal of Molecular Recognition
Vol/bind20
Udgave nummer6
Sider (fra-til)554-560
Antal sider7
ISSN0952-3499
DOI
StatusUdgivet - 2007
Eksternt udgivetJa
BegivenhedAFM BioMed 2007, Atomic force microscopy in life sciences and medicine - Barcelona, Spanien
Varighed: 19 apr. 200721 apr. 2007

Konference

KonferenceAFM BioMed 2007, Atomic force microscopy in life sciences and medicine
LandSpanien
ByBarcelona
Periode19/04/200721/04/2007

ID: 230977523