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Linear Peptides Are the Major Products of a Biosynthetic Pathway That Encodes for Cyclic Depsipeptides

Publikation: Bidrag til tidsskriftLetterForskningfagfællebedømt

  • Thomas P. Wyche
  • Antonio C. Ruzzini
  • Christine Beemelmanns
  • Ki Hyun Kim
  • Jonathan L. Klassen
  • Shugeng Cao
  • Poulsen, Michael
  • Tim S. Bugni
  • Cameron R. Currie
  • Jon Clardy

Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The structures of the complex nonribosomal peptide synthetase-polyketide synthase (NRPS/PKS) hybrid compounds were determined by 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Both cyclic and linear peptides are reported, and the genetic organization of the NRPS modules within the biosynthetic gene cluster accounts for the observed structural diversity.

OriginalsprogEngelsk
TidsskriftOrganic Letters
Vol/bind19
Udgave nummer7
Sider (fra-til)1772-1775
Antal sider4
ISSN1523-7060
DOI
StatusUdgivet - 2017
Eksternt udgivetJa

ID: 199558504