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Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G--possible implications for human reproduction and autoimmune disease

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Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G--possible implications for human reproduction and autoimmune disease. / Hviid, Thomas Vauvert F; Christiansen, Ole B.

I: Human Immunology, Bind 66, Nr. 6, 06.2005, s. 688-99.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Hviid, TVF & Christiansen, OB 2005, 'Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G--possible implications for human reproduction and autoimmune disease', Human Immunology, bind 66, nr. 6, s. 688-99. https://doi.org/10.1016/j.humimm.2005.03.003

APA

Hviid, T. V. F., & Christiansen, O. B. (2005). Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G--possible implications for human reproduction and autoimmune disease. Human Immunology, 66(6), 688-99. https://doi.org/10.1016/j.humimm.2005.03.003

Vancouver

Hviid TVF, Christiansen OB. Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G--possible implications for human reproduction and autoimmune disease. Human Immunology. 2005 jun;66(6):688-99. https://doi.org/10.1016/j.humimm.2005.03.003

Author

Hviid, Thomas Vauvert F ; Christiansen, Ole B. / Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G--possible implications for human reproduction and autoimmune disease. I: Human Immunology. 2005 ; Bind 66, Nr. 6. s. 688-99.

Bibtex

@article{bd101c546983444b83f0078649b841fa,
title = "Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G--possible implications for human reproduction and autoimmune disease",
abstract = "A line of investigation indicates that one or several genes in the human major histocompatibility complex (MHC) influences reproductive success. Studies have revealed associations between human leukocyte antigen (HLA) class II genes and risk of recurrent spontaneous abortion (RSA) and pre-eclampsia. However, these genes are not expressed at the feto-maternal interface. Furthermore, associations between polymorphisms in the nonclassical HLA class Ib gene, HLA-G, and reproductive outcome have been demonstrated. HLA-G is expressed by extravillous trophoblast during pregnancy, making it a more obvious candidate gene for a possible influence on pregnancy outcome. HLA-G has immunomodulatory functions. We have studied linkage disequilibrium between HLA class II genes, primarily HLA-DRB1 alleles, and HLA-G alleles in women with RSA and their partners (n = 103) and in control women and their partners (n = 92). We found a significant linkage disequilibrium between HLA-DR3 and HLA-G*010102 in both the RSA and control populations. For all four studied HLA loci, the alleles in the haplotype HLA-DRB1*03.DQA1*05.DQB1*02.G*010102 was in clear linkage disequilibrium. This HLA haplotype has repeatedly been associated with different autoimmune diseases but also with RSA. The G*010102 allele includes a 14-bp sequence polymorphism in the 3' untranslated region of the gene, which has been associated with differences in HLA-G mRNA alternative splicing and stability. This 14-bp polymorphism has also been associated with RSA, pre-eclampsia, and outcome of in vitro fertilization. Implications of HLA polymorphism--and other polymorphic genes in the MHC for pregnancy outcome--and for autoimmune diseases during pregnancy are discussed.",
keywords = "Abortion, Habitual, Alleles, Autoimmune Diseases, Female, Fertility, Genetic Predisposition to Disease, HLA Antigens, HLA-DQ Antigens, HLA-DQ alpha-Chains, HLA-DQ beta-Chains, HLA-DR Antigens, HLA-DR3 Antigen, HLA-DRB1 Chains, HLA-G Antigens, Haplotypes, Histocompatibility Antigens Class I, Humans, Linkage Disequilibrium, Male, Pregnancy, Pregnancy Complications, Journal Article, Research Support, Non-U.S. Gov't",
author = "Hviid, {Thomas Vauvert F} and Christiansen, {Ole B}",
year = "2005",
month = "6",
doi = "10.1016/j.humimm.2005.03.003",
language = "English",
volume = "66",
pages = "688--99",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G--possible implications for human reproduction and autoimmune disease

AU - Hviid, Thomas Vauvert F

AU - Christiansen, Ole B

PY - 2005/6

Y1 - 2005/6

N2 - A line of investigation indicates that one or several genes in the human major histocompatibility complex (MHC) influences reproductive success. Studies have revealed associations between human leukocyte antigen (HLA) class II genes and risk of recurrent spontaneous abortion (RSA) and pre-eclampsia. However, these genes are not expressed at the feto-maternal interface. Furthermore, associations between polymorphisms in the nonclassical HLA class Ib gene, HLA-G, and reproductive outcome have been demonstrated. HLA-G is expressed by extravillous trophoblast during pregnancy, making it a more obvious candidate gene for a possible influence on pregnancy outcome. HLA-G has immunomodulatory functions. We have studied linkage disequilibrium between HLA class II genes, primarily HLA-DRB1 alleles, and HLA-G alleles in women with RSA and their partners (n = 103) and in control women and their partners (n = 92). We found a significant linkage disequilibrium between HLA-DR3 and HLA-G*010102 in both the RSA and control populations. For all four studied HLA loci, the alleles in the haplotype HLA-DRB1*03.DQA1*05.DQB1*02.G*010102 was in clear linkage disequilibrium. This HLA haplotype has repeatedly been associated with different autoimmune diseases but also with RSA. The G*010102 allele includes a 14-bp sequence polymorphism in the 3' untranslated region of the gene, which has been associated with differences in HLA-G mRNA alternative splicing and stability. This 14-bp polymorphism has also been associated with RSA, pre-eclampsia, and outcome of in vitro fertilization. Implications of HLA polymorphism--and other polymorphic genes in the MHC for pregnancy outcome--and for autoimmune diseases during pregnancy are discussed.

AB - A line of investigation indicates that one or several genes in the human major histocompatibility complex (MHC) influences reproductive success. Studies have revealed associations between human leukocyte antigen (HLA) class II genes and risk of recurrent spontaneous abortion (RSA) and pre-eclampsia. However, these genes are not expressed at the feto-maternal interface. Furthermore, associations between polymorphisms in the nonclassical HLA class Ib gene, HLA-G, and reproductive outcome have been demonstrated. HLA-G is expressed by extravillous trophoblast during pregnancy, making it a more obvious candidate gene for a possible influence on pregnancy outcome. HLA-G has immunomodulatory functions. We have studied linkage disequilibrium between HLA class II genes, primarily HLA-DRB1 alleles, and HLA-G alleles in women with RSA and their partners (n = 103) and in control women and their partners (n = 92). We found a significant linkage disequilibrium between HLA-DR3 and HLA-G*010102 in both the RSA and control populations. For all four studied HLA loci, the alleles in the haplotype HLA-DRB1*03.DQA1*05.DQB1*02.G*010102 was in clear linkage disequilibrium. This HLA haplotype has repeatedly been associated with different autoimmune diseases but also with RSA. The G*010102 allele includes a 14-bp sequence polymorphism in the 3' untranslated region of the gene, which has been associated with differences in HLA-G mRNA alternative splicing and stability. This 14-bp polymorphism has also been associated with RSA, pre-eclampsia, and outcome of in vitro fertilization. Implications of HLA polymorphism--and other polymorphic genes in the MHC for pregnancy outcome--and for autoimmune diseases during pregnancy are discussed.

KW - Abortion, Habitual

KW - Alleles

KW - Autoimmune Diseases

KW - Female

KW - Fertility

KW - Genetic Predisposition to Disease

KW - HLA Antigens

KW - HLA-DQ Antigens

KW - HLA-DQ alpha-Chains

KW - HLA-DQ beta-Chains

KW - HLA-DR Antigens

KW - HLA-DR3 Antigen

KW - HLA-DRB1 Chains

KW - HLA-G Antigens

KW - Haplotypes

KW - Histocompatibility Antigens Class I

KW - Humans

KW - Linkage Disequilibrium

KW - Male

KW - Pregnancy

KW - Pregnancy Complications

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.humimm.2005.03.003

DO - 10.1016/j.humimm.2005.03.003

M3 - Journal article

C2 - 15993714

VL - 66

SP - 688

EP - 699

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

IS - 6

ER -

ID: 188691652