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Linking Microbiota to Human Diseases: A Systems Biology Perspective

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

The human gut microbiota encompasses a densely populated ecosystem that provides essential functions for host development, immune maturation, and metabolism. Alterations to the gut microbiota have been observed in numerous diseases, including human metabolic diseases such as obesity, type 2 diabetes (T2D), and irritable bowel syndrome, and some animal experiments have suggested causality. However, few studies have validated causality in humans and the underlying mechanisms remain largely to be elucidated. We discuss how systems biology approaches combined with new experimental technologies may disentangle some of the mechanistic details in the complex interactions of diet, microbiota, and host metabolism and may provide testable hypotheses for advancing our current understanding of human-microbiota interaction.

OriginalsprogEngelsk
TidsskriftTrends in Endocrinology and Metabolism
Vol/bind26
Udgave nummer12
Sider (fra-til)758-70
Antal sider13
ISSN1043-2760
DOI
StatusUdgivet - 6 nov. 2015

ID: 150712119