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Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function. / Andersen, Ove; Haugaard, Steen B; Andersen, Ulrik B; Friis-Møller, Nina; Storgaard, Heidi; Vølund, Aage; Nielsen, Jens Ole; Iversen, Johan; Madsbad, Sten.

I: Metabolism, Bind 52, Nr. 10, 2003, s. 1343-53.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Andersen, O, Haugaard, SB, Andersen, UB, Friis-Møller, N, Storgaard, H, Vølund, A, Nielsen, JO, Iversen, J & Madsbad, S 2003, 'Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function', Metabolism, bind 52, nr. 10, s. 1343-53.

APA

Andersen, O., Haugaard, S. B., Andersen, U. B., Friis-Møller, N., Storgaard, H., Vølund, A., ... Madsbad, S. (2003). Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function. Metabolism, 52(10), 1343-53.

Vancouver

Andersen O, Haugaard SB, Andersen UB, Friis-Møller N, Storgaard H, Vølund A o.a. Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function. Metabolism. 2003;52(10):1343-53.

Author

Andersen, Ove ; Haugaard, Steen B ; Andersen, Ulrik B ; Friis-Møller, Nina ; Storgaard, Heidi ; Vølund, Aage ; Nielsen, Jens Ole ; Iversen, Johan ; Madsbad, Sten. / Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function. I: Metabolism. 2003 ; Bind 52, Nr. 10. s. 1343-53.

Bibtex

@article{3f915d9d8eea44f0925b1f4a3a484729,
title = "Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function",
abstract = "The pathophysiology of insulin resistance in human immunodeficiency virus (HIV)-associated lipodystrophy syndrome (HALS) is not fully clarified. We investigated 18 men with HALS and 18 HIV-positive males without lipodystrophy (control subjects). Duration and modality of antiretroviral therapy were similar between study groups. A hyperinsulinemic euglycemic clamp showed an impaired glucose disposal rate (GDR) in HALS patients (5.6 v 8.3 mg glucose/min. kg(FFM), P =.0006). As demonstrated by indirect calorimetry, HALS patients showed an impaired nonoxidative glucose metabolism (NOGM, 2.2 v 4.2, P =.006), whereas levels of basal and insulin-stimulated oxidative glucose metabolism (OGM) (2.4 v 2.3, P =.55, and 3.3 v 4.0, P =.064, respectively) were not significantly different between groups. Despite comparable total fat masses, dual energy x-ray absorptiometry (DEXA) scans showed that the percentage of limb fat (ie, peripheral-fat-mass/[peripheral-fat-mass + trunk-fat-mass]. 100{\%}) was reduced in HALS patients (36{\%} v 46{\%}, P =.0002). Multiple linear regression analysis indicated that percentage of limb fat explained 53{\%} of the variability of GDR and 45{\%} of the variability of NOGM in HALS patients. In HALS patients, leg fat mass correlated positively with NOGM (r =.51, P <.05), whereas abdominal fat mass and NOGM did not correlate (P =.91). Analyzing the relationship between first phase insulin secretion and insulin sensitivity, 6 HALS patients compared with none of the control subjects exhibited impaired insulin secretion (P <.05). Our data suggest that fat redistribution independently of antiretroviral therapy is highly related to insulin resistance in HALS patients. Furthermore, in HALS patients, impaired glucose metabolism most likely relates to decreased NOGM and to defects in beta-cell function.",
author = "Ove Andersen and Haugaard, {Steen B} and Andersen, {Ulrik B} and Nina Friis-M{\o}ller and Heidi Storgaard and Aage V{\o}lund and Nielsen, {Jens Ole} and Johan Iversen and Sten Madsbad",
year = "2003",
language = "English",
volume = "52",
pages = "1343--53",
journal = "Metabolism",
issn = "0026-0495",
publisher = "Elsevier",
number = "10",

}

RIS

TY - JOUR

T1 - Lipodystrophy in human immunodeficiency virus patients impairs insulin action and induces defects in beta-cell function

AU - Andersen, Ove

AU - Haugaard, Steen B

AU - Andersen, Ulrik B

AU - Friis-Møller, Nina

AU - Storgaard, Heidi

AU - Vølund, Aage

AU - Nielsen, Jens Ole

AU - Iversen, Johan

AU - Madsbad, Sten

PY - 2003

Y1 - 2003

N2 - The pathophysiology of insulin resistance in human immunodeficiency virus (HIV)-associated lipodystrophy syndrome (HALS) is not fully clarified. We investigated 18 men with HALS and 18 HIV-positive males without lipodystrophy (control subjects). Duration and modality of antiretroviral therapy were similar between study groups. A hyperinsulinemic euglycemic clamp showed an impaired glucose disposal rate (GDR) in HALS patients (5.6 v 8.3 mg glucose/min. kg(FFM), P =.0006). As demonstrated by indirect calorimetry, HALS patients showed an impaired nonoxidative glucose metabolism (NOGM, 2.2 v 4.2, P =.006), whereas levels of basal and insulin-stimulated oxidative glucose metabolism (OGM) (2.4 v 2.3, P =.55, and 3.3 v 4.0, P =.064, respectively) were not significantly different between groups. Despite comparable total fat masses, dual energy x-ray absorptiometry (DEXA) scans showed that the percentage of limb fat (ie, peripheral-fat-mass/[peripheral-fat-mass + trunk-fat-mass]. 100%) was reduced in HALS patients (36% v 46%, P =.0002). Multiple linear regression analysis indicated that percentage of limb fat explained 53% of the variability of GDR and 45% of the variability of NOGM in HALS patients. In HALS patients, leg fat mass correlated positively with NOGM (r =.51, P <.05), whereas abdominal fat mass and NOGM did not correlate (P =.91). Analyzing the relationship between first phase insulin secretion and insulin sensitivity, 6 HALS patients compared with none of the control subjects exhibited impaired insulin secretion (P <.05). Our data suggest that fat redistribution independently of antiretroviral therapy is highly related to insulin resistance in HALS patients. Furthermore, in HALS patients, impaired glucose metabolism most likely relates to decreased NOGM and to defects in beta-cell function.

AB - The pathophysiology of insulin resistance in human immunodeficiency virus (HIV)-associated lipodystrophy syndrome (HALS) is not fully clarified. We investigated 18 men with HALS and 18 HIV-positive males without lipodystrophy (control subjects). Duration and modality of antiretroviral therapy were similar between study groups. A hyperinsulinemic euglycemic clamp showed an impaired glucose disposal rate (GDR) in HALS patients (5.6 v 8.3 mg glucose/min. kg(FFM), P =.0006). As demonstrated by indirect calorimetry, HALS patients showed an impaired nonoxidative glucose metabolism (NOGM, 2.2 v 4.2, P =.006), whereas levels of basal and insulin-stimulated oxidative glucose metabolism (OGM) (2.4 v 2.3, P =.55, and 3.3 v 4.0, P =.064, respectively) were not significantly different between groups. Despite comparable total fat masses, dual energy x-ray absorptiometry (DEXA) scans showed that the percentage of limb fat (ie, peripheral-fat-mass/[peripheral-fat-mass + trunk-fat-mass]. 100%) was reduced in HALS patients (36% v 46%, P =.0002). Multiple linear regression analysis indicated that percentage of limb fat explained 53% of the variability of GDR and 45% of the variability of NOGM in HALS patients. In HALS patients, leg fat mass correlated positively with NOGM (r =.51, P <.05), whereas abdominal fat mass and NOGM did not correlate (P =.91). Analyzing the relationship between first phase insulin secretion and insulin sensitivity, 6 HALS patients compared with none of the control subjects exhibited impaired insulin secretion (P <.05). Our data suggest that fat redistribution independently of antiretroviral therapy is highly related to insulin resistance in HALS patients. Furthermore, in HALS patients, impaired glucose metabolism most likely relates to decreased NOGM and to defects in beta-cell function.

M3 - Journal article

VL - 52

SP - 1343

EP - 1353

JO - Metabolism

JF - Metabolism

SN - 0026-0495

IS - 10

ER -

ID: 34067710