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Local release of ATP into the arterial inflow and venous drainage of human skeletal muscle: insight from ATP determination with the intravascular microdialysis technique

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  • Stefan Mortensen
  • Pia Thaning
  • Michael Permin Nyberg
  • Bengt Saltin
  • Hellsten, Ylva
Intraluminal ATP could play an important role in the local regulation of skeletal muscle blood flow, but the stimuli that cause ATP release and the levels of plasma ATP in vessels supplying and draining human skeletal muscle remain unclear. To gain insight into the mechanisms by which ATP is released into plasma, we measured plasma [ATP] with the intravascular microdialysis technique at rest and during dynamic exercise (normoxia and hypoxia), passive exercise, thigh compressions and arterial ATP, tyramine and ACh infusion in a total of 16 healthy young men. Femoral arterial and venous[ATP] were 109±34 and 147±45 nmol l(-1) at rest and increased to 363±83 and 560±111 nmol l(-1), respectively, during exercise (P
OriginalsprogEngelsk
TidsskriftJournal of Physiology
Vol/bind589
Udgave nummer7
Sider (fra-til)1847-1857
Antal sider11
ISSN0022-3751
DOI
StatusUdgivet - 2011

Bibliografisk note

CURIS 2011 5200 018

ID: 32904837