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Long-term follow-up of kidney transplant patients with posttransplant lymphoproliferative disorder: duration of posttransplant lymphoproliferative disorder-induced operational graft tolerance, interleukin-18 course, and results of retransplantation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Søren Birkeland
  • Stephen Jacques Hamilton Dutoit
  • K Bendtzen
Posttransplant lymphoproliferative disorder (PTLD) can be resolved in many transplant patients by the reduction or cessation of immunosuppression, after which many grafts continue to function as the result of a form of operational tolerance. When graft function deteriorates, retransplantation may be an option. Cytokines such as interleukin (IL)-10 and IL-18 may play a role in PTLD tolerance induction and tumor regression. We report long-term follow-up on the duration of graft tolerance and the course of retransplantation in a series of patients who underwent kidney transplantation and demonstrated PTLD, and in whom we were able to perform IL-18 analyses.
OriginalsprogEngelsk
TidsskriftTransplantation
Vol/bind76
Udgave nummer1
Sider (fra-til)153-8
Antal sider6
ISSN0041-1337
DOI
StatusUdgivet - 15 jul. 2003

ID: 34101980