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Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Bronchoalveolar Fluid and Lung Tissue in Cardiac Surgery Patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Bronchoalveolar Fluid and Lung Tissue in Cardiac Surgery Patients. / Maltesen, Raluca G.; Buggeskov, Katrine B.; Andersen, Claus B.; Plovsing, Ronni; Wimmer, Reinhard; Ravn, Hanne B.; Rasmussen, Bodil S.

I: Metabolites, Bind 8, Nr. 4, 54, 01.12.2018, s. 1-15.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Maltesen, RG, Buggeskov, KB, Andersen, CB, Plovsing, R, Wimmer, R, Ravn, HB & Rasmussen, BS 2018, 'Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Bronchoalveolar Fluid and Lung Tissue in Cardiac Surgery Patients', Metabolites, bind 8, nr. 4, 54, s. 1-15. https://doi.org/10.3390/metabo8040054

APA

Maltesen, R. G., Buggeskov, K. B., Andersen, C. B., Plovsing, R., Wimmer, R., Ravn, H. B., & Rasmussen, B. S. (2018). Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Bronchoalveolar Fluid and Lung Tissue in Cardiac Surgery Patients. Metabolites, 8(4), 1-15. [54]. https://doi.org/10.3390/metabo8040054

Vancouver

Maltesen RG, Buggeskov KB, Andersen CB, Plovsing R, Wimmer R, Ravn HB o.a. Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Bronchoalveolar Fluid and Lung Tissue in Cardiac Surgery Patients. Metabolites. 2018 dec 1;8(4):1-15. 54. https://doi.org/10.3390/metabo8040054

Author

Maltesen, Raluca G. ; Buggeskov, Katrine B. ; Andersen, Claus B. ; Plovsing, Ronni ; Wimmer, Reinhard ; Ravn, Hanne B. ; Rasmussen, Bodil S. / Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Bronchoalveolar Fluid and Lung Tissue in Cardiac Surgery Patients. I: Metabolites. 2018 ; Bind 8, Nr. 4. s. 1-15.

Bibtex

@article{6e2ff93415a64971ade3c53bedb41309,
title = "Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Bronchoalveolar Fluid and Lung Tissue in Cardiac Surgery Patients",
abstract = "Pulmonary dysfunction is among the most frequent complications to cardiac surgeries. Exposure of blood to the cardiopulmonary bypass (CPB) circuit with subsequent lung ischemia-reperfusion leads to the production of inflammatory mediators and increases in microvascular permeability. The study aimed to elucidate histological, cellular, and metabolite changes following two lung protective regimens during CPB with Histidine-Tryptophan-Ketoglutarate (HTK) enriched or warm oxygenated blood pulmonary perfusion compared to standard regimen with no pulmonary perfusion. A total of 90 patients undergoing CPB were randomized to receiving HTK, oxygenated blood or standard regimen. Of these, bronchoalveolar lavage fluid (BALF) and lung tissue biopsies were obtained before and after CPB from 47 and 25 patients, respectively. Histopathological scores, BALF cell counts and metabolite screening were assessed. Multivariate and univariate analyses were performed. Profound histological, cellular, and metabolic changes were identified in all patients after CPB. Histological and cellular changes were similar in the three groups; however, some metabolite profiles were different in the HTK patients. While all patients presented an increase in inflammatory cells, metabolic acidosis, protease activity and oxidative stress, HTK patients seemed to be protected against severe acidosis, excessive fatty acid oxidation, and inflammation during ischemia-reperfusion. Additional studies are needed to confirm these findings.",
keywords = "Bronchoalveolar lavage, CPB, HTK, Inflammation, Ischemia-reperfusion injury, Lung biopsy, Lung protection, Metabolites, NMR, Oxygenated blood",
author = "Maltesen, {Raluca G.} and Buggeskov, {Katrine B.} and Andersen, {Claus B.} and Ronni Plovsing and Reinhard Wimmer and Ravn, {Hanne B.} and Rasmussen, {Bodil S.}",
year = "2018",
month = "12",
day = "1",
doi = "10.3390/metabo8040054",
language = "English",
volume = "8",
pages = "1--15",
journal = "Metabolites",
issn = "2218-1989",
publisher = "M D P I AG",
number = "4",

}

RIS

TY - JOUR

T1 - Lung Protection Strategies during Cardiopulmonary Bypass Affect the Composition of Bronchoalveolar Fluid and Lung Tissue in Cardiac Surgery Patients

AU - Maltesen, Raluca G.

AU - Buggeskov, Katrine B.

AU - Andersen, Claus B.

AU - Plovsing, Ronni

AU - Wimmer, Reinhard

AU - Ravn, Hanne B.

AU - Rasmussen, Bodil S.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Pulmonary dysfunction is among the most frequent complications to cardiac surgeries. Exposure of blood to the cardiopulmonary bypass (CPB) circuit with subsequent lung ischemia-reperfusion leads to the production of inflammatory mediators and increases in microvascular permeability. The study aimed to elucidate histological, cellular, and metabolite changes following two lung protective regimens during CPB with Histidine-Tryptophan-Ketoglutarate (HTK) enriched or warm oxygenated blood pulmonary perfusion compared to standard regimen with no pulmonary perfusion. A total of 90 patients undergoing CPB were randomized to receiving HTK, oxygenated blood or standard regimen. Of these, bronchoalveolar lavage fluid (BALF) and lung tissue biopsies were obtained before and after CPB from 47 and 25 patients, respectively. Histopathological scores, BALF cell counts and metabolite screening were assessed. Multivariate and univariate analyses were performed. Profound histological, cellular, and metabolic changes were identified in all patients after CPB. Histological and cellular changes were similar in the three groups; however, some metabolite profiles were different in the HTK patients. While all patients presented an increase in inflammatory cells, metabolic acidosis, protease activity and oxidative stress, HTK patients seemed to be protected against severe acidosis, excessive fatty acid oxidation, and inflammation during ischemia-reperfusion. Additional studies are needed to confirm these findings.

AB - Pulmonary dysfunction is among the most frequent complications to cardiac surgeries. Exposure of blood to the cardiopulmonary bypass (CPB) circuit with subsequent lung ischemia-reperfusion leads to the production of inflammatory mediators and increases in microvascular permeability. The study aimed to elucidate histological, cellular, and metabolite changes following two lung protective regimens during CPB with Histidine-Tryptophan-Ketoglutarate (HTK) enriched or warm oxygenated blood pulmonary perfusion compared to standard regimen with no pulmonary perfusion. A total of 90 patients undergoing CPB were randomized to receiving HTK, oxygenated blood or standard regimen. Of these, bronchoalveolar lavage fluid (BALF) and lung tissue biopsies were obtained before and after CPB from 47 and 25 patients, respectively. Histopathological scores, BALF cell counts and metabolite screening were assessed. Multivariate and univariate analyses were performed. Profound histological, cellular, and metabolic changes were identified in all patients after CPB. Histological and cellular changes were similar in the three groups; however, some metabolite profiles were different in the HTK patients. While all patients presented an increase in inflammatory cells, metabolic acidosis, protease activity and oxidative stress, HTK patients seemed to be protected against severe acidosis, excessive fatty acid oxidation, and inflammation during ischemia-reperfusion. Additional studies are needed to confirm these findings.

KW - Bronchoalveolar lavage

KW - CPB

KW - HTK

KW - Inflammation

KW - Ischemia-reperfusion injury

KW - Lung biopsy

KW - Lung protection

KW - Metabolites

KW - NMR

KW - Oxygenated blood

UR - http://www.scopus.com/inward/record.url?scp=85054745082&partnerID=8YFLogxK

U2 - 10.3390/metabo8040054

DO - 10.3390/metabo8040054

M3 - Journal article

C2 - 30241409

AN - SCOPUS:85054745082

VL - 8

SP - 1

EP - 15

JO - Metabolites

JF - Metabolites

SN - 2218-1989

IS - 4

M1 - 54

ER -

ID: 210837326